Q8BN74 · Q8BN74_MOUSE
- ProteinNuclear receptor coactivator 2
- GeneNcoa2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids873 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q8BN74
GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.
- CategoriesSequences, Interaction
- SourceMGI: 1276533
Cited inMapped toSIRT6 promotes hepatic beta-oxidation via activation of PPARalpha.
- CategoryInteraction
- SourceMGI: 1276533
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
- CategoriesFunction, Interaction
- SourceMGI: 1276533
The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis.
- CategoryInteraction
- SourceMGI: 1276533
Estrogen receptor alpha/beta, AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance?
- AnnotationER beta AIB1 and TIF2 appear to be involved in colorectal tumorigenesis and might have prognostic significance.
- CategoriesFunction, Interaction
- SourceGeneRif: 17978
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor- mediated immunosuppression.
- AnnotationCompetition with glucocorticoid receptor for GRIP1 antagonizes IRF3-mediated transcription.
- CategoryInteraction
RORgammat recruits steroid receptor coactivators to ensure thymocyte survival.
- CategoryInteraction
- SourceMGI: 1276533
GAC63, a GRIP1-dependent nuclear receptor coactivator.
- CategoryInteraction
- SourceMGI: 1276533
Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice.
- AnnotationTIF2 serves as the preferential coactivator for androgen receptor in testis.
- CategoriesFunction, Interaction
Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness.
- AnnotationRb enhances the activity of nuclear receptors through direct interactions with NGFI-B and SRC-2.
- CategoriesFunction, Interaction
- SourceGeneRif: 17978
Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation.
- AnnotationGRIP1 interaction and activation of mCAR in the nucleus result in retention and accumulation of mCAR in the nucleus; model requires that mCAR constantly shuttle between the nucleus and cytoplasm
- CategoryInteraction
Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.
- AnnotationBoth SRC1A and p/CIP function as coactivators for MyoD-mediated transcription whereas GRIP1 acts negatively as a (co)repressor; supressor of MyoD
- CategoryInteraction
- SourceGeneRif: 17978
Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor- mediated transcription.
- CategoryInteraction
- SourceMGI: 1276533
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.
- Annotationdata demonstrate that GRIP1 is ubiquitinated and degraded through activation of the PKA pathway
- CategoryInteraction
Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.
- CategoryInteraction
- SourceMGI: 1276533
CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators.
- CategoryInteraction
- SourceMGI: 1276533
Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.
- AnnotationTIF2/GRIP1 coactivation of androgen receptor transactivation in recurrent prostate cancer is increased by EGF signaling through MAPK
- CategoryInteraction
- SourceGeneRif: 17978