Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cells.
The JMJD2B-dependent upregulation of PPARgamma2 was associated with the removal of di- and trimethylation of histone H3 lysine 9 on the promoter of PPARgamma2. Furthermore exogeneous expression of JMJD2B using adenovirus in mice resulted in hepatic steatosis when fed a HFD which was accompanied with increased expression of hepatic PPARgamma2 and its steatosis target genes.
JMJD2B-deficient mice exhibited hyperactive behavior sustained hyperactivity in a novel environment deficits in working memory and spontaneous epileptic-like seizures.
KDM4B histone demethylase regulates expression of myogenic regulators such as MyoD and thereby controls myogenic differentiation of C2C12 myoblast cells.
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