Q8BL65 · ABLM2_MOUSE
- ProteinActin-binding LIM protein 2
- GeneAblim2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids612 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 86 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 103 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 106 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 109 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 112 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 131 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 134 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 212 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 215 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 232 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 235 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 238 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 241 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 260 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 263 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | myofibril | |
Molecular Function | actin filament binding | |
Molecular Function | metal ion binding | |
Biological Process | cytoskeleton organization | |
Biological Process | lamellipodium assembly | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | transcription by RNA polymerase II |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameActin-binding LIM protein 2
- Short namesabLIM-2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BL65
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: In skeletal muscle, sarcomeric or cosarcomeric localization.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000075700 | 1-612 | Actin-binding LIM protein 2 | |||
Sequence: MSAVSQPQAAHAPLEKPASTAILCNTCGNVCKGEVLRVQNKYFHIRCFVCKACGCDLAEGGFFVRQGEHICTRDYQRLYGTRCFSCDRFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSPPTLLGNSAHVAQGLRSCGGCGLEIKNGQALVALDKHWHLGCFKCKTCGKLLNAEYISKDGLPYCEADYHSKFGIRCDGCEKYITGRVLEAGEKHYHPSCALCVRCGQMFSEGEEMYLQGSSIWHPACRQAARTEDKSKETRTSSESIVSVPASSTSGSPSRVIYAKLGDEILDYRDLAALPKNKAIYNIDRPDMISYSPYISHSAVGDRQSYGEGDQDDRSYKQCRTSSPSSAGSVSLGHYTPTSRSPQHYSRPGSESGRSTPSLSVHSDSRPPSSTYQQAPRHFHVPDTGVKDNIYRKPPIYKQHAARRLDVEDSSFDQDSRKKTTWLLLKGDADTRTNSPDLDSQSLSLSSGTDQEPLQRMAGDSLYSRFPYSKPDTLPGPRKDGLDLRNANLAPCGADPDASWGTREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF | ||||||
Modified residue | 282 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 294 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 351 | In isoform Q8BL65-4; Phosphoserine | ||||
Sequence: G | ||||||
Modified residue | 356 | In isoform Q8BL65-4; Phosphoserine | ||||
Sequence: R | ||||||
Modified residue | 365 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 368 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 453 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 473 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 477 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 579 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain. Highly expressed in caudate/putamen, moderately expressed in the olfactory bulb. In the hippocampus, expressed in the CA1, CA2 and CA3 fields. In the cerebellum, expressed in Purkinje cells.
Developmental stage
At 15.5 dpc, predominantly expressed in skeletal muscle tissue, including diaphragm, and to a lesser extent in the central nervous system.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-81 | LIM zinc-binding 1 | ||||
Sequence: ILCNTCGNVCKGEVLRVQNKYFHIRCFVCKACGCDLAEGGFFVRQGEHICTRDYQRLYGT | ||||||
Domain | 81-141 | LIM zinc-binding 2 | ||||
Sequence: TRCFSCDRFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSPPTLLG | ||||||
Domain | 151-210 | LIM zinc-binding 3 | ||||
Sequence: RSCGGCGLEIKNGQALVALDKHWHLGCFKCKTCGKLLNAEYISKDGLPYCEADYHSKFGI | ||||||
Domain | 210-270 | LIM zinc-binding 4 | ||||
Sequence: IRCDGCEKYITGRVLEAGEKHYHPSCALCVRCGQMFSEGEEMYLQGSSIWHPACRQAARTE | ||||||
Region | 269-295 | Disordered | ||||
Sequence: TEDKSKETRTSSESIVSVPASSTSGSP | ||||||
Compositional bias | 279-295 | Polar residues | ||||
Sequence: SSESIVSVPASSTSGSP | ||||||
Region | 341-433 | Disordered | ||||
Sequence: AVGDRQSYGEGDQDDRSYKQCRTSSPSSAGSVSLGHYTPTSRSPQHYSRPGSESGRSTPSLSVHSDSRPPSSTYQQAPRHFHVPDTGVKDNIY | ||||||
Compositional bias | 360-419 | Polar residues | ||||
Sequence: QCRTSSPSSAGSVSLGHYTPTSRSPQHYSRPGSESGRSTPSLSVHSDSRPPSSTYQQAPR | ||||||
Region | 471-498 | Disordered | ||||
Sequence: ADTRTNSPDLDSQSLSLSSGTDQEPLQR | ||||||
Compositional bias | 476-496 | Polar residues | ||||
Sequence: NSPDLDSQSLSLSSGTDQEPL | ||||||
Domain | 544-612 | HP | ||||
Sequence: TREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q8BL65-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length612
- Mass (Da)68,107
- Last updated2003-03-01 v1
- Checksum97FE5A9C049AD455
Q8BL65-2
- Name2
- Differences from canonical
- 507-546: RFPYSKPDTLPGPRKDGLDLRNANLAPCGADPDASWGTRE → Q
Q8BL65-3
- Name3
Q8BL65-4
- Name4
Q8BL65-5
- Name5
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 279-295 | Polar residues | ||||
Sequence: SSESIVSVPASSTSGSP | ||||||
Sequence conflict | 305 | in Ref. 3; BAC32905 | ||||
Sequence: D → N | ||||||
Alternative sequence | VSP_012120 | 350 | in isoform 4 | |||
Sequence: E → ESPQLLSPTPTE | ||||||
Compositional bias | 360-419 | Polar residues | ||||
Sequence: QCRTSSPSSAGSVSLGHYTPTSRSPQHYSRPGSESGRSTPSLSVHSDSRPPSSTYQQAPR | ||||||
Alternative sequence | VSP_012121 | 390 | in isoform 3, isoform 4 and isoform 5 | |||
Sequence: P → PAGTVSVGTSSCLSLSQHPSPTSVFRHHYIPYFR | ||||||
Sequence conflict | 406 | in Ref. 3; BAC32905 | ||||
Sequence: D → N | ||||||
Compositional bias | 476-496 | Polar residues | ||||
Sequence: NSPDLDSQSLSLSSGTDQEPL | ||||||
Alternative sequence | VSP_012123 | 507-526 | in isoform 5 | |||
Sequence: RFPYSKPDTLPGPRKDGLDL → QCQPGPLWSRPGCQLGHARV | ||||||
Alternative sequence | VSP_012122 | 507-546 | in isoform 2, isoform 3 and isoform 4 | |||
Sequence: RFPYSKPDTLPGPRKDGLDLRNANLAPCGADPDASWGTRE → Q | ||||||
Alternative sequence | VSP_012124 | 527-612 | in isoform 5 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ748602 EMBL· GenBank· DDBJ | CAG38377.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ748603 EMBL· GenBank· DDBJ | CAG38378.1 EMBL· GenBank· DDBJ | mRNA | ||
AY274116 EMBL· GenBank· DDBJ | AAP23233.1 EMBL· GenBank· DDBJ | mRNA | ||
AK046243 EMBL· GenBank· DDBJ | BAC32651.1 EMBL· GenBank· DDBJ | mRNA | ||
AK046879 EMBL· GenBank· DDBJ | BAC32905.1 EMBL· GenBank· DDBJ | mRNA | ||
AK082707 EMBL· GenBank· DDBJ | BAC38580.1 EMBL· GenBank· DDBJ | mRNA | ||
BC141125 EMBL· GenBank· DDBJ | AAI41126.1 EMBL· GenBank· DDBJ | mRNA |