Q8BL48 · UNK_MOUSE

  • Protein
    RING finger protein unkempt homolog
  • Gene
    Unk
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular FunctionmRNA CDS binding
Molecular Functionribosome binding
Biological Processcell morphogenesis involved in neuron differentiation
Biological Processin utero embryonic development
Biological Processnegative regulation of cytoplasmic translation
Biological Processneuron migration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RING finger protein unkempt homolog
  • Alternative names
    • Zinc finger CCCH domain-containing protein 5

Gene names

    • Name
      Unk
    • Synonyms
      Kiaa1753, Zc3h5, Zc3hdc5

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BL48
  • Secondary accessions
    • A2A853
    • Q8BVI6
    • Q99JZ8
    • Q99LL9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002139001-810RING finger protein unkempt homolog
Modified residue240Phosphoserine
Modified residue374Phosphoserine
Modified residue378Phosphoserine
Modified residue385Phosphoserine
Modified residue394Phosphoserine
Modified residue631Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

First expressed at 12 dpc and then expression declines postnatally. Highly expressed in the developing CNS (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, zinc finger, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region1-24Disordered
Zinc finger84-113C3H1-type 1
Zinc finger124-154C3H1-type 2
Zinc finger215-241C3H1-type 3
Region239-265Disordered
Compositional bias242-256Basic residues
Zinc finger251-285C3H1-type 4
Zinc finger293-321C3H1-type 5
Region478-497Disordered
Coiled coil643-727
Zinc finger766-801RING-type; degenerate

Sequence similarities

Belongs to the unkempt family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8BL48-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    810
  • Mass (Da)
    88,058
  • Last updated
    2003-03-01 v1
  • Checksum
    78BA9F07530E92B5
MSKGPGPGGSAASSAPPAATAQVLQAQPEKPQHYTYLKEFRTEQCPLFVQHKCTQHRPYTCFHWHFVNQRRRRSIRRRDGTFNYSPDVYCTKYDEATGLCPEGDECPFLHRTTGDTERRYHLRYYKTGICIHETDSKGNCTKNGLHCAFAHGPHDLRSPVYDIRELQAMEALQNGQTTVEGSIEGQSAGAASHAMIEKILSEEPRWQETAYVLGNYKTEPCKKPPRLCRQGYACPYYHNSKDRRRSPRKHKYRSSPCPNVKHGDEWGDPGKCENGDACQYCHTRTEQQFHPEIYKSTKCNDMQQAGSCPRGPFCAFAHIEPPPLSDDVQPSSAVSSPTQPGPVLYMPSAAGDSVPVSPSSPHAPDLSALLCRNSGLGSPSHLCSSPPGPSRKASNLEGLVFPGESSLAPGSYKKAPGFEREDQVGAEYLKNFKCQAKLKPHSLEPRSQEQPLLQPKQDVLGILPVGSPLTSSISSSITSSLAATPPSPAGTNSTPGMNANALPFYPTSDTVESVIESALDDLDLNEFGVAALEKTFDNSAVPHPSSVTIGGSLLQSSAPVNIPGSLGSSASFHSASPSPPVSLSSHFLQQPQGHLSQSENTFLGTSASHGSLGLNGMNSSIWEHFASGSFSPGTSPAFLSGPGAAELARLRQELDEANGTIKQWEESWKQAKQACDAWKKEAEEAGERASAAGAECELAREQRDALELRVKKLQEELERLHTVPEAQTLPAAPDLEALSLSTLYSIQKQLRVHLEQVDKAVFHMQSVKCLKCQEQTRAVLPCQHAVLCELCAEGSECPVCQPSRAHALQS

Q8BL48-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence BAC98248.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias242-256Basic residues
Alternative sequenceVSP_010274356-369in isoform 2
Sequence conflict634in Ref. 2; BAC37123

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK129438
EMBL· GenBank· DDBJ
BAC98248.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK046395
EMBL· GenBank· DDBJ
BAC32702.1
EMBL· GenBank· DDBJ
mRNA
AK078095
EMBL· GenBank· DDBJ
BAC37123.1
EMBL· GenBank· DDBJ
mRNA
AL607108
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC003195
EMBL· GenBank· DDBJ
AAH03195.1
EMBL· GenBank· DDBJ
mRNA
BC005545
EMBL· GenBank· DDBJ
AAH05545.1
EMBL· GenBank· DDBJ
mRNA
BC054452
EMBL· GenBank· DDBJ
AAH54452.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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