Q8BL48 · UNK_MOUSE
- ProteinRING finger protein unkempt homolog
- GeneUnk
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids810 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA CDS binding | |
Molecular Function | ribosome binding | |
Biological Process | cell morphogenesis involved in neuron differentiation | |
Biological Process | in utero embryonic development | |
Biological Process | negative regulation of cytoplasmic translation | |
Biological Process | neuron migration |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRING finger protein unkempt homolog
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BL48
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000213900 | 1-810 | RING finger protein unkempt homolog | |||
Sequence: MSKGPGPGGSAASSAPPAATAQVLQAQPEKPQHYTYLKEFRTEQCPLFVQHKCTQHRPYTCFHWHFVNQRRRRSIRRRDGTFNYSPDVYCTKYDEATGLCPEGDECPFLHRTTGDTERRYHLRYYKTGICIHETDSKGNCTKNGLHCAFAHGPHDLRSPVYDIRELQAMEALQNGQTTVEGSIEGQSAGAASHAMIEKILSEEPRWQETAYVLGNYKTEPCKKPPRLCRQGYACPYYHNSKDRRRSPRKHKYRSSPCPNVKHGDEWGDPGKCENGDACQYCHTRTEQQFHPEIYKSTKCNDMQQAGSCPRGPFCAFAHIEPPPLSDDVQPSSAVSSPTQPGPVLYMPSAAGDSVPVSPSSPHAPDLSALLCRNSGLGSPSHLCSSPPGPSRKASNLEGLVFPGESSLAPGSYKKAPGFEREDQVGAEYLKNFKCQAKLKPHSLEPRSQEQPLLQPKQDVLGILPVGSPLTSSISSSITSSLAATPPSPAGTNSTPGMNANALPFYPTSDTVESVIESALDDLDLNEFGVAALEKTFDNSAVPHPSSVTIGGSLLQSSAPVNIPGSLGSSASFHSASPSPPVSLSSHFLQQPQGHLSQSENTFLGTSASHGSLGLNGMNSSIWEHFASGSFSPGTSPAFLSGPGAAELARLRQELDEANGTIKQWEESWKQAKQACDAWKKEAEEAGERASAAGAECELAREQRDALELRVKKLQEELERLHTVPEAQTLPAAPDLEALSLSTLYSIQKQLRVHLEQVDKAVFHMQSVKCLKCQEQTRAVLPCQHAVLCELCAEGSECPVCQPSRAHALQS | ||||||
Modified residue | 240 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 374 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 378 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 385 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 394 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 631 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
First expressed at 12 dpc and then expression declines postnatally. Highly expressed in the developing CNS (at protein level).
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MSKGPGPGGSAASSAPPAATAQVL | ||||||
Zinc finger | 84-113 | C3H1-type 1 | ||||
Sequence: YSPDVYCTKYDEATGLCPEGDECPFLHRTT | ||||||
Zinc finger | 124-154 | C3H1-type 2 | ||||
Sequence: YYKTGICIHETDSKGNCTKNGLHCAFAHGPH | ||||||
Zinc finger | 215-241 | C3H1-type 3 | ||||
Sequence: NYKTEPCKKPPRLCRQGYACPYYHNSK | ||||||
Region | 239-265 | Disordered | ||||
Sequence: NSKDRRRSPRKHKYRSSPCPNVKHGDE | ||||||
Compositional bias | 242-256 | Basic residues | ||||
Sequence: DRRRSPRKHKYRSSP | ||||||
Zinc finger | 251-285 | C3H1-type 4 | ||||
Sequence: KYRSSPCPNVKHGDEWGDPGKCENGDACQYCHTRT | ||||||
Zinc finger | 293-321 | C3H1-type 5 | ||||
Sequence: IYKSTKCNDMQQAGSCPRGPFCAFAHIEP | ||||||
Region | 478-497 | Disordered | ||||
Sequence: TSSLAATPPSPAGTNSTPGM | ||||||
Coiled coil | 643-727 | |||||
Sequence: GAAELARLRQELDEANGTIKQWEESWKQAKQACDAWKKEAEEAGERASAAGAECELAREQRDALELRVKKLQEELERLHTVPEAQ | ||||||
Zinc finger | 766-801 | RING-type; degenerate | ||||
Sequence: SVKCLKCQEQTRAVLPCQHAVLCELCAEGSECPVCQ |
Sequence similarities
Belongs to the unkempt family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8BL48-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length810
- Mass (Da)88,058
- Last updated2003-03-01 v1
- Checksum78BA9F07530E92B5
Q8BL48-2
- Name2
- Differences from canonical
- 356-369: VSPSSPHAPDLSAL → L
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 242-256 | Basic residues | ||||
Sequence: DRRRSPRKHKYRSSP | ||||||
Alternative sequence | VSP_010274 | 356-369 | in isoform 2 | |||
Sequence: VSPSSPHAPDLSAL → L | ||||||
Sequence conflict | 634 | in Ref. 2; BAC37123 | ||||
Sequence: T → A |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK129438 EMBL· GenBank· DDBJ | BAC98248.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK046395 EMBL· GenBank· DDBJ | BAC32702.1 EMBL· GenBank· DDBJ | mRNA | ||
AK078095 EMBL· GenBank· DDBJ | BAC37123.1 EMBL· GenBank· DDBJ | mRNA | ||
AL607108 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC003195 EMBL· GenBank· DDBJ | AAH03195.1 EMBL· GenBank· DDBJ | mRNA | ||
BC005545 EMBL· GenBank· DDBJ | AAH05545.1 EMBL· GenBank· DDBJ | mRNA | ||
BC054452 EMBL· GenBank· DDBJ | AAH54452.1 EMBL· GenBank· DDBJ | mRNA |