We found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice. Social investigating behaviour of intact mGluR7 KO mice also differed from that of wild-type mice; e.g. the KO mice showing less frequent anogenital sniffing and more frequent grooming behaviour. Further castrated mGluR7 KO mice have smaller seminal vesicles than those of castrated wild-type mice although intact mice were no different.
mGlu7 is not functionally increased in mice overexpressing MeCP2 and that neither genetic nor pharmacological reduction of mGlu7 activity impacts phenotypes in a mouse model of MeCP2 duplication syndrome.
The mGlu7 receptor was found to be involved in a wide range of behavioral and physiological alterations in response to chronic psychosocial stress exposure.
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