High-efficiency full-length cDNA cloning.Carninci P., Hayashizaki Y.Cited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCMethods Enzymol 303:19-44 (1999)Cited in99+Mapped to15
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 10:1617-1630 (2000)Cited in199+Mapped to10
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K.[...], Togawa Y.View abstractCited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res 10:1757-1771 (2000)Cited in99+
Functional annotation of a full-length mouse cDNA collection.Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y., Arakawa T., Hara A., Fukunishi Y.[...], Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCNature 409:685-690 (2001)Cited in399+Mapped to99+
No title available.Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T.[...], Hayashizaki Y.Cited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to EMBL/GenBank/DDBJ databases (JUL-2001)Cited in299+
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R.[...], Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCNature 420:563-573 (2002)Cited in699+Mapped to99+
The Transcriptional Landscape of the Mammalian Genome.The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)Cited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)Science 309:1559-1563 (2005)Cited in199+
Antisense transcription in the mammalian transcriptome.FANTOM ConsortiumKatayama S., Tomaru Y., Kasukawa T., Waki K., Nakanishi M., Nakamura M., Nishida H., Yap C.C., Suzuki M.[...], Wahlestedt C.View abstractCited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueCorpus striatumCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCScience 309:1564-1566 (2005)Cited in99+
Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.Masugi M., Yokoi M., Shigemoto R., Muguruma K., Watanabe Y., Sansig G., van der Putten H., Nakanishi S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCJ Neurosci 19:955-963 (1999)Mapped to36
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.Kaupmann K., Huggel K., Heid J., Flor P.J., Bischoff S., Mickel S.J., McMaster G., Angst C., Bittiger H.[...], Bettler B.View abstractCategorySequencesSourceMGI: 1351344PubMedEurope PMCNature 386:239-246 (1997)Cited in1Mapped to58
Physiological Features of the Neural Stem Cells Obtained from an Animal Model of Spinal Muscular Atrophy and Their Response to Antioxidant Curcumin.Adami R., Pezzotta M., Cadile F., Cuniolo B., Rovati G., Canepari M., Bottai D.View abstractSourceMGI: 1351344PubMedEurope PMCInt J Mol Sci 25:8364-8364 (2024)Mapped to18
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing.Hatanaka F., Suzuki K., Shojima K., Yu J., Takahashi Y., Sakamoto A., Prieto J., Shokhirev M., Nunez Delicado E.[...], Izpisua Belmonte J.C.View abstractSourceMGI: 1351344PubMedEurope PMCNat Commun 15:6191-6191 (2024)Mapped to18
Systemic LPS Administration Stimulates the Activation of Non-Neuronal Cells in an Experimental Model of Spinal Muscular Atrophy.Karafoulidou E., Kesidou E., Theotokis P., Konstantinou C., Nella M.K., Michailidou I., Touloumi O., Polyzoidou E., Salamotas I.[...], Grigoriadis N.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCCells 13:785-785 (2024)Mapped to18
Improved gene therapy for spinal muscular atrophy in mice using codon- optimized hSMN1 transgene and hSMN1 gene-derived promotor.Xie Q., Chen X., Ma H., Zhu Y., Ma Y., Jalinous L., Cox G.F., Weaver F., Yang J.[...], Xie J.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCEMBO Mol Med 16:945-965 (2024)Mapped to18
mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS.Kumar V., Lee K.Y., Acharya A., Babik M.S., Christian-Hinman C.A., Rhodes J.S., Tsai N.P.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCEMBO Mol Med 16:506-522 (2024)Mapped to21
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy.Miller N., Xu Z., Quinlan K.A., Ji A., McGivern J.V., Feng Z., Shi H., Ko C.P., Tsai L.H.[...], Ma Y.C.View abstractSourceMGI: 1351344PubMedEurope PMCProc Natl Acad Sci U S A 120:e2300308120-e2300308120 (2023)Mapped to26
SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy.Valsecchi V., Errico F., Bassareo V., Marino C., Nuzzo T., Brancaccio P., Laudati G., Casamassa A., Grimaldi M.[...], Usiello A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCCommun Biol 6:1155-1155 (2023)Mapped to43
Diaphragm Fatigue in SMNDelta7 Mice and Its Molecular Determinants: An Underestimated Issue.Cadile F., Recchia D., Ansaldo M., Rossi P., Rastelli G., Boncompagni S., Brocca L., Pellegrino M.A., Canepari M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCInt J Mol Sci 24:14953-14953 (2023)Mapped to18
PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.Kordala A.J., Stoodley J., Ahlskog N., Hanifi M., Garcia Guerra A., Bhomra A., Lim W.F., Murray L.M., Talbot K.[...], Rinaldi C.View abstractAnnotationPRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.CategoryNamesSourceGeneRif: 108073PubMedEurope PMCEMBO Mol Med 15:e17683-e17683 (2023)Mapped to6
Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy.Lumpkin C.J., Harris A.W., Connell A.J., Kirk R.W., Whiting J.A., Saieva L., Pellizzoni L., Burghes A.H.M., Butchbach M.E.R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCSci Rep 13:10374-10374 (2023)Mapped to18
MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice.Chen T.H., Chang S.H., Wu Y.F., Yen Y.P., Hsu F.Y., Chen Y.C., Ming Y., Hsu H.C., Su Y.C.[...], Chen J.A.View abstractCategoryNamesSourceMGI: 1351344PubMedEurope PMCMol Ther Nucleic Acids 32:144-160 (2023)Mapped to18
Base editing rescue of spinal muscular atrophy in cells and in mice.Arbab M., Matuszek Z., Kray K.M., Du A., Newby G.A., Blatnik A.J., Raguram A., Richter M.F., Zhao K.T.[...], Liu D.R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCScience 380:eadg6518-eadg6518 (2023)Mapped to18
A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.Kim J.K., Jha N.N., Awano T., Caine C., Gollapalli K., Welby E., Kim S.S., Fuentes-Moliz A., Wang X.[...], Monani U.R.View abstractAnnotationA spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.CategoryFunctionSourceGeneRif: 108073, MGI: 1351344PubMedEurope PMCNeuron 111:1423-1439.e4 (2023)Mapped to41
Potentiation of neuromuscular transmission by a small molecule calcium channel gating modifier improves motor function in a severe spinal muscular atrophy mouse model.Ojala K.S., Kaufhold C.J., Davey M.R., Yang D., Liang M., Wipf P., Badawi Y., Meriney S.D.View abstractCategoryNamesSourceMGI: 1351344PubMedEurope PMCHum Mol Genet 32:1901-1911 (2023)Mapped to18
Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons.Miralles M.P., Sansa A., Beltran M., Soler R.M., Garcera A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCFront Cell Neurosci 16:1054270-1054270 (2022)Mapped to18
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.Hennlein L., Ghanawi H., Gerstner F., Palominos Garcia E., Yildirim E., Saal-Bauernschubert L., Moradi M., Deng C., Klein T.[...], Jablonka S.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCJ Cell Biol 222:e202204113-e202204113 (2023)Mapped to36
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.Ikenaka A., Kitagawa Y., Yoshida M., Lin C.Y., Niwa A., Nakahata T., Saito M.K.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCLife Sci Alliance 6:e202201457-e202201457 (2023)Mapped to39
Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.Boido M., Gesmundo I., Caretto A., Pedrolli F., Schellino R., Leone S., Cai R., Sha W., Ghigo E.[...], Granata R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCProc Natl Acad Sci U S A 120:e2216814120-e2216814120 (2023)Mapped to18
p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models.Buettner J.M., Sowoidnich L., Gerstner F., Blanco-Redondo B., Hallermann S., Simon C.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCFront Cell Neurosci 16:1038276-1038276 (2022)Mapped to26
Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation.Masugi-Tokita M., Kubota S., Kobayashi K., Yoshida T., Kageyama S., Sakamoto H., Kawauchi A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCNeuroscience 509:10-19 (2023)Mapped to9
SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models.Franco-Espin J., Gatius A., Armengol J.A., Arumugam S., Moradi M., Sendtner M., Caldero J., Tabares L.View abstractCategoriesFamily & Domains, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCBiomolecules 12:1524-1524 (2022)Mapped to22
SMN controls neuromuscular junction integrity through U7 snRNP.Tisdale S., Van Alstyne M., Simon C.M., Mentis G.Z., Pellizzoni L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCCell Rep 40:111393-111393 (2022)Mapped to18
Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience.Woschitz V., Mei I., Hedlund E., Murray L.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCSkelet Muscle 12:22-22 (2022)Mapped to18
Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn2B/- mouse model of SMA.Carlini M.J., Triplett M.K., Pellizzoni L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCPLoS One 17:e0267990-e0267990 (2022)Mapped to18
Glutamate can act as a signaling molecule in mouse preimplantation embryos†.Spirkova A., Kovarikova V., Sefcikova Z., Pisko J., Ksinanova M., Koppel J., Fabian D., Cikos S.View abstractCategoriesFunction, ExpressionSourceMGI: 1351344PubMedEurope PMCBiol Reprod 107:916-927 (2022)Mapped to99+
Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy.Marasco L.E., Dujardin G., Sousa-Luis R., Liu Y.H., Stigliano J.N., Nomakuchi T., Proudfoot N.J., Krainer A.R., Kornblihtt A.R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCCell 185:2057-2070.e15 (2022)Mapped to18
Motor unit recovery following Smn restoration in mouse models of spinal muscular atrophy.Comley L.H., Kline R.A., Thomson A.K., Woschitz V., Landeros E.V., Osman E.Y., Lorson C.L., Murray L.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCHum Mol Genet 31:3107-3119 (2022)Mapped to18
Survival motor neuron protein deficiency alters microglia reactivity.Khayrullina G., Alipio-Gloria Z.A., Deguise M.O., Gagnon S., Chehade L., Stinson M., Belous N., Bergman E.M., Lischka F.W.[...], Burnett B.G.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCGlia 70:1337-1358 (2022)Mapped to25
Antisense oligonucleotides targeting the SMN2 promoter region enhance SMN2 expression in spinal muscular atrophy cell lines and mouse model.Wang J., Bai J., OuYang S., Wang H., Jin Y., Peng X., Ge X., Jiao H., Zou J.[...], Qu Y.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCHum Mol Genet 31:1635-1650 (2022)Mapped to18
Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models.Buettner J.M., Sime Longang J.K., Gerstner F., Apel K.S., Blanco-Redondo B., Sowoidnich L., Janzen E., Langenhan T., Wirth B., Simon C.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCiScience 24:103376-103376 (2021)Mapped to18
SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples.Abiusi E., Infante P., Cagnoli C., Lospinoso Severini L., Pane M., Coratti G., Pera M.C., D'Amico A., Diano F.[...], Tiziano F.D.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCElife 10:e68054-e68054 (2021)Mapped to18
Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice.Kray K.M., McGovern V.L., Chugh D., Arnold W.D., Burghes A.H.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCNeurobiol Dis 159:105488-105488 (2021)Mapped to18
Sumoylation regulates the assembly and activity of the SMN complex.Riboldi G.M., Faravelli I., Kuwajima T., Delestree N., Dermentzaki G., De Planell-Saguer M., Rinchetti P., Hao L.T., Beattie C.C.[...], Lotti F.View abstractCategoriesFunction, InteractionSourceMGI: 1351344PubMedEurope PMCNat Commun 12:5040-5040 (2021)Mapped to39
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression.Zhao X., Feng Z., Risher N., Mollin A., Sheedy J., Ling K.K.Y., Narasimhan J., Dakka A., Baird J.D.[...], Weetall M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCHum Mol Genet 31:82-96 (2021)Mapped to44
Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA).Feng Z., Lam S., Tenn E.S., Ghosh A.S., Cantor S., Zhang W., Yen P.F., Chen K.S., Burden S.[...], Ko C.P.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCInt J Mol Sci 22:8015-8015 (2021)Mapped to27
Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons.Sansa A., Hidalgo I., Miralles M.P., de la Fuente S., Perez-Garcia M.J., Munell F., Soler R.M., Garcera A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCActa Neuropathol Commun 9:122-122 (2021)Mapped to19
Dysregulation of Muscle-Specific MicroRNAs as Common Pathogenic Feature Associated with Muscle Atrophy in ALS, SMA and SBMA: Evidence from Animal Models and Human Patients.Malacarne C., Galbiati M., Giagnorio E., Cavalcante P., Salerno F., Andreetta F., Cagnoli C., Taiana M., Nizzardo M.[...], Marcuzzo S.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCInt J Mol Sci 22:5673-5673 (2021)Mapped to19
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit.Van Alstyne M., Tattoli I., Delestree N., Recinos Y., Workman E., Shihabuddin L.S., Zhang C., Mentis G.Z., Pellizzoni L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCNat Neurosci 24:930-940 (2021)Mapped to18
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA.Kong L., Valdivia D.O., Simon C.M., Hassinan C.W., Delestree N., Ramos D.M., Park J.H., Pilato C.M., Xu X.[...], Sumner C.J.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCSci Transl Med 13:eabb6871-eabb6871 (2021)Mapped to24