Q8BIW9 · CTF18_MOUSE

  • Protein
    Chromosome transmission fidelity protein 18 homolog
  • Gene
    Chtf18
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.

Features

Showing features for binding site.

1969100200300400500600700800900
TypeIDPosition(s)Description
Binding site369-376ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentCtf18 RFC-like complex
Cellular Componentcytoplasm
Cellular Componentmale germ cell nucleus
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Biological Processchromosome segregation
Biological ProcessDNA duplex unwinding
Biological ProcessDNA replication
Biological Processgerm cell development
Biological Processmale meiotic nuclear division
Biological Processnegative regulation of chromosome segregation
Biological Processpositive regulation of DNA-directed DNA polymerase activity
Biological Processreciprocal meiotic recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chromosome transmission fidelity protein 18 homolog

Gene names

    • Name
      Chtf18
    • Synonyms
      Ctf18

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BIW9
  • Secondary accessions
    • Q8R1R7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003400821-969Chromosome transmission fidelity protein 18 homolog
Modified residue51Phosphothreonine
Modified residue221Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1. The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21. Interacts with DDX11.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region30-97Disordered
Region250-269Disordered
Region318-340Disordered
Region856-889Disordered
Compositional bias860-878Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    969
  • Mass (Da)
    108,137
  • Last updated
    2008-06-10 v2
  • Checksum
    E0269C507AF514BD
MEDYEEDLYGVEDDFQNQFAAELEVLAELEGTRDQAPPGTLQTPASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVVKKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNRNPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVPFASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEATAPGKWKSHEQALEEMLEAELDPSQRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGVGGRPNCLVIDEIDGAPTAAINVLLGILNRKGPQEADQGGTAVAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALVALCEKTDNDIRACINTLQFLYGRGRRELSVKAVQTTHVGLKDQRKGLFSVWQEVFQLPRTQRRIVGQDLMLPAHALLLSNGDKGSLTLASQRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLSTVCCALDWLAFDDLLEQAAHRGQSFQLLCYLPFVPAAFHVLFASSHVPRITFPSSQQEAQTRMSQTRNHIQTLVSGMAPTTRSRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWARSGPQVDQGSSGPASLWTDSGEKGTRQPAPRNHEQRLEHIMKRATVQEQPERDFFGRVVIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PVJ3E9PVJ3_MOUSEChtf18970
A0A0R4J0I4A0A0R4J0I4_MOUSEChtf18969
E9Q2M3E9Q2M3_MOUSEChtf18365
F6ZBE7F6ZBE7_MOUSEChtf18130
F6YVH6F6YVH6_MOUSEChtf18109

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias860-878Polar residues
Sequence conflict880in Ref. 2; AAH24142
Sequence conflict885in Ref. 1; BAC37079
Sequence conflict898in Ref. 1; BAC37079

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK077947
EMBL· GenBank· DDBJ
BAC37079.1
EMBL· GenBank· DDBJ
mRNA
BC024142
EMBL· GenBank· DDBJ
AAH24142.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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