Q8BIT5 · Q8BIT5_MOUSE
- ProteinZdhhc17 protein
- GeneZdhhc17
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids124 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q8BIT5
S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.
- AnnotationS-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.
- CategoriesFunction, Interaction, Phenotypes & Variants
- SourceGeneRif: 320150
Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.
- AnnotationCoupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.
- CategoriesFunction
Molecular basis of fatty acid selectivity in the zDHHC family of S- acyltransferases revealed by click chemistry.
- CategoriesFunction, PTM / Processing
- SourceMGI: 2445110
Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.
- AnnotationThese data suggest that HIP14 is essential for maintenance of life and neuronal integrity in the adult mouse.
- CategoriesFunction, Phenotypes & Variants
Palmitoylation of caspase-6 by HIP14 regulates its activation.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 2445110
ZDHHC17 promotes axon outgrowth by regulating TrkA-tubulin complex formation.
- AnnotationThe findings of this study identify ZDHHC17 as an important upstream factor of ERK1/2 to regulate the interaction between TrkA and tubulin during neuronal development.
- CategoriesFunction, Phenotypes & Variants
Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases.
- AnnotationData show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 recognize peptide sequence in several unrelated proteins.
- CategoriesFunction
Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.
- AnnotationLoss of Hip14 and Hip14l leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion.
- CategoriesFunction
Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
- AnnotationData indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.
- CategoriesFunction
- SourceGeneRif: 320150
Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14).
- AnnotationIn the absence of HIP14 striatal neurons become dysfunctional leading to impaired motor behavior.
- CategoriesFunction
Memory and synaptic deficits in Hip14/DHHC17 knockout mice.
- AnnotationThe constitutive absence of Hip14/DHHC17 results in major neurophysiological deficits and associated cognitive dysfunction.
- CategoriesFunction
DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane.
- CategoriesInteraction
- SourceMGI: 2445110
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
- CategoriesInteraction
- SourceMGI: 2445110
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
- Annotationaltered palmitoylation mediated by HIP14 may contribute to HD.
- CategoriesFunction
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
- AnnotationImmunohistochemical analysis of pancreatic sections demonstrated that HIP14 is almost exclusively expressed in insulin-positive cells in islets of Langerhans.
- CategoriesFunction, Interaction, Subcellular Location
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
- AnnotationWild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
- CategoriesFunction
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
- CategoriesExpression
- SourceMGI: 2445110
Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport.
- Annotationhuntingtin interacting protein genes HIP14 and HIP14L encode Mg2+ transport proteins that are regulated by their innate palmitoyl acyltransferases thus fulfilling the characteristics of "chanzymes."
- CategoriesFunction, Expression
Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.
- CategoriesPTM / Processing, Subcellular Location
- SourceMGI: 2445110
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
- AnnotationDownregulation of HIP14 in mouse neurons expressing wild-type and mutant htt increases inclusion formation whereas overexpression of HIP14 substantially reduces inclusions
- CategoriesFunction, PTM / Processing
- SourceGeneRif: 320150
The transcriptional landscape of the mammalian genome.
- CategoriesSequences
- SourceMGI: 2445110