Q8BHF7 · PGPS1_MOUSE
- ProteinCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
- GenePgs1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids553 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Catalytic activity
- a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H+
Activity regulation
Activated by calcium and magnesium and inhibited by other bivalent cations.
Pathway
Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | |
Biological Process | cardiolipin biosynthetic process | |
Biological Process | diacylglycerol metabolic process | |
Biological Process | phosphatidylglycerol biosynthetic process | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BHF7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-25 | Mitochondrion | ||||
Sequence: MAAPAAGPVFWRRLLGLLPGRPGLA | ||||||
Chain | PRO_0000337107 | 26-553 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial | |||
Sequence: ALLGRLSDRLGRSRERRRRRSPWLLLAPLLSPTVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIKIAKRRVVMASLYLGTGPLEQELVDCLESSLEKSLQAKFPSDLKVSILLDFTRGSRGRKNSRTMLLPLLQRFPERVRVSLFHTPNLRGLLRLLIPERFNETIGLQHIKVYLFDNNVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVEVVDGMVHPYKGDRAAYCRAANKRVMDVIHSARARQQMLHAQTFHSDSLLSQEEAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVFLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFYSEVCSLGQQDRVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTESRSLQQQLHQEQEQLYLRSGVVTSATFEQPGRQVKLWVKMVTPLIKNFF | ||||||
Modified residue | 46 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed with higher expression in testis, liver and brain.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 212-238 | PLD phosphodiesterase 1 | ||||
Sequence: TIGLQHIKVYLFDNNVILSGANLSDSY | ||||||
Domain | 457-490 | PLD phosphodiesterase 2 | ||||
Sequence: RGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRS |
Sequence similarities
Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length553
- Mass (Da)62,489
- Last updated2003-03-01 v1
- Checksum23373FEE4E47CD46
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 371 | in Ref. 4; AAH22918 | ||||
Sequence: T → M |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK046174 EMBL· GenBank· DDBJ | BAC32619.1 EMBL· GenBank· DDBJ | mRNA | ||
AK049359 EMBL· GenBank· DDBJ | BAC33708.1 EMBL· GenBank· DDBJ | mRNA | ||
AK053905 EMBL· GenBank· DDBJ | BAC35584.1 EMBL· GenBank· DDBJ | mRNA | ||
AL591433 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AF411101 EMBL· GenBank· DDBJ | AAL87040.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
BC022918 EMBL· GenBank· DDBJ | AAH22918.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |