Q8BHF7 · PGPS1_MOUSE

  • Protein
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
  • Gene
    Pgs1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.

Catalytic activity

Activity regulation

Activated by calcium and magnesium and inhibited by other bivalent cations.

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site121-128ATP (UniProtKB | ChEBI)
Active site217
Active site219
Active site224

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular FunctionCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
Biological Processcardiolipin biosynthetic process
Biological Processdiacylglycerol metabolic process
Biological Processphosphatidylglycerol biosynthetic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
  • EC number
  • Alternative names
    • Phosphatidylglycerophosphate synthase 1 (PGP synthase 1)
    • Silencer-associated factor

Gene names

    • Name
      Pgs1
    • Synonyms
      Saf

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • BALB/cJ
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BHF7
  • Secondary accessions
    • Q8QZT9
    • Q8R4R7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-25Mitochondrion
ChainPRO_000033710726-553CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
Modified residue46Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed with higher expression in testis, liver and brain.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain212-238PLD phosphodiesterase 1
Domain457-490PLD phosphodiesterase 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    553
  • Mass (Da)
    62,489
  • Last updated
    2003-03-01 v1
  • Checksum
    23373FEE4E47CD46
MAAPAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRSRERRRRRSPWLLLAPLLSPTVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIKIAKRRVVMASLYLGTGPLEQELVDCLESSLEKSLQAKFPSDLKVSILLDFTRGSRGRKNSRTMLLPLLQRFPERVRVSLFHTPNLRGLLRLLIPERFNETIGLQHIKVYLFDNNVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVEVVDGMVHPYKGDRAAYCRAANKRVMDVIHSARARQQMLHAQTFHSDSLLSQEEAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVFLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFYSEVCSLGQQDRVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTESRSLQQQLHQEQEQLYLRSGVVTSATFEQPGRQVKLWVKMVTPLIKNFF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WI04F8WI04_MOUSEPgs1476
F2Z427F2Z427_MOUSEPgs1347

Sequence caution

The sequence AAH22918.1 differs from that shown. Reason: Erroneous initiation
The sequence AAL87040.1 differs from that shown. Reason: Miscellaneous discrepancy Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict371in Ref. 4; AAH22918

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK046174
EMBL· GenBank· DDBJ
BAC32619.1
EMBL· GenBank· DDBJ
mRNA
AK049359
EMBL· GenBank· DDBJ
BAC33708.1
EMBL· GenBank· DDBJ
mRNA
AK053905
EMBL· GenBank· DDBJ
BAC35584.1
EMBL· GenBank· DDBJ
mRNA
AL591433
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AF411101
EMBL· GenBank· DDBJ
AAL87040.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
BC022918
EMBL· GenBank· DDBJ
AAH22918.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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