Q8BH75 · RNF41_MOUSE
- ProteinE3 ubiquitin-protein ligase NRDP1
- GeneRnf41
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids317 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity).
Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718).
Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327).
Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718).
Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327).
Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase NRDP1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BH75
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000223955 | 1-317 | E3 ubiquitin-protein ligase NRDP1 | |||
Sequence: MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI |
Post-translational modification
Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with USP8, ERBB3, PRKN and BIRC6 (By similarity).
Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with Clec16a (PubMed:24949970).
Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with Clec16a (PubMed:24949970).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8BH75 | Clec16a Q80U30-2 | 3 | EBI-7059583, EBI-9696757 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 18-57 | RING-type; degenerate | ||||
Sequence: CPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDR | ||||||
Zinc finger | 78-138 | SIAH-type; degenerate | ||||
Sequence: KLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8BH75-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length317
- Mass (Da)35,891
- Last updated2003-03-01 v1
- Checksum43FE844C06392802
Q8BH75-2
- Name2
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1W2P811 | A0A1W2P811_MOUSE | Rnf41 | 122 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 7 | in Ref. 1; BAC31779 | ||||
Sequence: R → H | ||||||
Alternative sequence | VSP_058649 | 31-36 | in isoform 2 | |||
Sequence: APHCEH → PGDAQR | ||||||
Alternative sequence | VSP_058650 | 37-317 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 104 | in Ref. 2; AAH19415 | ||||
Sequence: S → T | ||||||
Sequence conflict | 156 | in Ref. 2; AAH19415 | ||||
Sequence: S → R | ||||||
Sequence conflict | 178 | in Ref. 1; BAC28054 | ||||
Sequence: R → Q | ||||||
Sequence conflict | 278 | in Ref. 1; BAB29953 | ||||
Sequence: K → E |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK015745 EMBL· GenBank· DDBJ | BAB29953.1 EMBL· GenBank· DDBJ | mRNA | ||
AK020527 EMBL· GenBank· DDBJ | BAB32125.1 EMBL· GenBank· DDBJ | mRNA | ||
AK028551 EMBL· GenBank· DDBJ | BAC26004.1 EMBL· GenBank· DDBJ | mRNA | ||
AK030558 EMBL· GenBank· DDBJ | BAC27020.1 EMBL· GenBank· DDBJ | mRNA | ||
AK031657 EMBL· GenBank· DDBJ | BAC27496.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK032848 EMBL· GenBank· DDBJ | BAC28054.1 EMBL· GenBank· DDBJ | mRNA | ||
AK034551 EMBL· GenBank· DDBJ | BAC28750.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044103 EMBL· GenBank· DDBJ | BAC31779.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK077466 EMBL· GenBank· DDBJ | BAC36813.1 EMBL· GenBank· DDBJ | mRNA | ||
BC019415 EMBL· GenBank· DDBJ | AAH19415.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC049078 EMBL· GenBank· DDBJ | AAH49078.1 EMBL· GenBank· DDBJ | mRNA |