Q8BH75 · RNF41_MOUSE

  • Protein
    E3 ubiquitin-protein ligase NRDP1
  • Gene
    Rnf41
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity).
Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718).
Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327).
Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum tubular network
Cellular Componentperinuclear region of cytoplasm
Molecular Functionerythropoietin receptor binding
Molecular Functionidentical protein binding
Molecular Functioninterleukin-3 receptor binding
Molecular Functionprotein domain specific binding
Molecular Functionreceptor tyrosine kinase binding
Molecular Functionsmall GTPase binding
Molecular Functionubiquitin protein ligase activity
Molecular Functionubiquitin-protein transferase activity
Molecular Functionzinc ion binding
Biological Processautophagy
Biological Processextrinsic apoptotic signaling pathway
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of mitophagy
Biological Processpositive regulation of protein catabolic process
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processproteasomal protein catabolic process
Biological Processprotein autoubiquitination
Biological Processprotein polyubiquitination
Biological Processprotein ubiquitination
Biological Processregulation of lymphocyte differentiation
Biological Processregulation of MAPK cascade
Biological Processregulation of myeloid cell differentiation
Biological Processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase NRDP1
  • EC number
  • Alternative names
    • RING finger protein 41
    • RING-type E3 ubiquitin transferase NRDP1

Gene names

    • Name
      Rnf41
    • Synonyms
      Flrf, Nrdp1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BH75
  • Secondary accessions
    • Q8BGJ2
    • Q8BMC9
    • Q8VEA2
    • Q9CRK6
    • Q9D568

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002239551-317E3 ubiquitin-protein ligase NRDP1

Post-translational modification

Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with USP8, ERBB3, PRKN and BIRC6 (By similarity).
Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with Clec16a (PubMed:24949970).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8BH75Clec16a Q80U30-23EBI-7059583, EBI-9696757

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for zinc finger.

TypeIDPosition(s)Description
Zinc finger18-57RING-type; degenerate
Zinc finger78-138SIAH-type; degenerate

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8BH75-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    317
  • Mass (Da)
    35,891
  • Last updated
    2003-03-01 v1
  • Checksum
    43FE844C06392802
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

Q8BH75-2

  • Name
    2
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W2P811A0A1W2P811_MOUSERnf41122

Sequence caution

The sequence AAH19415.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAC27496.1 differs from that shown. Reason: Erroneous translation Wrong choice of CDS.
The sequence BAC31779.1 differs from that shown. Reason: Erroneous translation Wrong choice of CDS.

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict7in Ref. 1; BAC31779
Alternative sequenceVSP_05864931-36in isoform 2
Alternative sequenceVSP_05865037-317in isoform 2
Sequence conflict104in Ref. 2; AAH19415
Sequence conflict156in Ref. 2; AAH19415
Sequence conflict178in Ref. 1; BAC28054
Sequence conflict278in Ref. 1; BAB29953

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK015745
EMBL· GenBank· DDBJ
BAB29953.1
EMBL· GenBank· DDBJ
mRNA
AK020527
EMBL· GenBank· DDBJ
BAB32125.1
EMBL· GenBank· DDBJ
mRNA
AK028551
EMBL· GenBank· DDBJ
BAC26004.1
EMBL· GenBank· DDBJ
mRNA
AK030558
EMBL· GenBank· DDBJ
BAC27020.1
EMBL· GenBank· DDBJ
mRNA
AK031657
EMBL· GenBank· DDBJ
BAC27496.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK032848
EMBL· GenBank· DDBJ
BAC28054.1
EMBL· GenBank· DDBJ
mRNA
AK034551
EMBL· GenBank· DDBJ
BAC28750.1
EMBL· GenBank· DDBJ
mRNA
AK044103
EMBL· GenBank· DDBJ
BAC31779.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK077466
EMBL· GenBank· DDBJ
BAC36813.1
EMBL· GenBank· DDBJ
mRNA
BC019415
EMBL· GenBank· DDBJ
AAH19415.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC049078
EMBL· GenBank· DDBJ
AAH49078.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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