Q8BH00 · AL8A1_MOUSE
- Protein2-aminomuconic semialdehyde dehydrogenase
- GeneAldh8a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids487 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
Catalytic activity
- 2-aminomuconate 6-semialdehyde + H2O + NAD+ = (2Z,4E)-2-aminomuconate + 2 H+ + NADH
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
2.3 μM | 9-cis-retinal |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
3.4 nmol/min/mg |
Activity was measured with total soluble protein.
Pathway
Amino-acid degradation; L-kynurenine degradation.
Features
Showing features for site, binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | aminomuconate-semialdehyde dehydrogenase activity | |
Molecular Function | retinal dehydrogenase activity | |
Biological Process | 9-cis-retinoic acid biosynthetic process | |
Biological Process | L-kynurenine catabolic process | |
Biological Process | retinal metabolic process | |
Biological Process | retinoic acid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-aminomuconic semialdehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BH00
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 145 | in strain: FVB/N | ||||
Sequence: V → G |
Variants
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The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000312955 | 1-487 | 2-aminomuconic semialdehyde dehydrogenase | |||
Sequence: MAGKRELLMLENFIGGKFLPCNSYIDSYDPSTGEVYCKVPNSGKEEIEAAVEAAREAFPAWSSRSPQERSLVLNRLADVLEQSLEELAQAESKDQGKTLTLARTMDIPRSVLNFRFFASSNLHHVSECTQMSHLGCMHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSEMTSVTAWMFCKLLDKAGVPPGVINIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLEECIPATVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEATRKWKVGVPSDPSANMGALISKAHLEKVRSYVLKAQTEGARILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESRCMTEEIFGPVTCVVPFDSEEEVITRANSVRYGLAATVWSKDVGRIHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIKY | ||||||
Modified residue | 362 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in hepatocytes and in proximal and distal convoluted tubules in kidney cortex (at protein level). Highly expressed in adult liver and in kidney cortex. First detected in embryonic liver after 15 days of development.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length487
- Mass (Da)53,664
- Last updated2003-03-01 v1
- Checksum5E205A495BD61ED7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF510322 EMBL· GenBank· DDBJ | AAO64246.1 EMBL· GenBank· DDBJ | mRNA | ||
AK050298 EMBL· GenBank· DDBJ | BAC34173.1 EMBL· GenBank· DDBJ | mRNA | ||
AK143752 EMBL· GenBank· DDBJ | BAE25524.1 EMBL· GenBank· DDBJ | mRNA | ||
BC013511 EMBL· GenBank· DDBJ | AAH13511.1 EMBL· GenBank· DDBJ | mRNA | ||
BC038493 EMBL· GenBank· DDBJ | AAH38493.1 EMBL· GenBank· DDBJ | mRNA |