Q8BGE4 · SUSD6_MOUSE
- ProteinSushi domain-containing protein 6
- GeneSusd6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids302 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (By similarity).
Plays a role in preventing tumor onset (PubMed:24652652).
Plays a role in preventing tumor onset (PubMed:24652652).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Biological Process | DNA damage response |
Names & Taxonomy
Protein names
- Recommended nameSushi domain-containing protein 6
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BGE4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 120-140 | Helical | ||||
Sequence: IVASTASSVALILLLVVLFVL |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice are viable and fertile and do not show any notable developmental defect or spontaneous tumor development within 2 years. SUSD6 and TP53 double knockout mice show an increase in tumor development and a decrease in lifespan compared to TP53 knockout mice carrying wild-type SUSD6 (PubMed:24652652).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-39 | |||||
Sequence: MCHGKIAPKSSSEFVVTSVGHGVFLQLVILCALLGDGLA | ||||||
Chain | PRO_0000432223 | 40-302 | Sushi domain-containing protein 6 | |||
Sequence: SVCPLPPEPENGGYICHPRPCKDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWTPAMEVSCHLIEDKETHALGVPALSIVASTASSVALILLLVVLFVLLQPKLKSFHHSRREQGVSGDQVSIMVDGVQVALPSYEEAVYGSSGHCMPPADPRVQIVLSEGSAPSGRNMPREQQLQGQEACSSAGGEDEAPGHSGLCEAWGSQGSETVMVHQATTSSWVAGSGSSRPTHKDTADSENSDIQSLLSLTSEEYTDDIPLLKEA | ||||||
Disulfide bond | 42↔89 | |||||
Sequence: CPLPPEPENGGYICHPRPCKDPLTAGSVIEYLCAEGYMLKGDYKYLTC | ||||||
Disulfide bond | 74↔102 | |||||
Sequence: CAEGYMLKGDYKYLTCKNGEWTPAMEVSC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 40-104 | Sushi | ||||
Sequence: SVCPLPPEPENGGYICHPRPCKDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWTPAMEVSCHL | ||||||
Region | 202-241 | Disordered | ||||
Sequence: GSAPSGRNMPREQQLQGQEACSSAGGEDEAPGHSGLCEAW | ||||||
Compositional bias | 207-222 | Polar residues | ||||
Sequence: GRNMPREQQLQGQEAC | ||||||
Region | 256-302 | Disordered | ||||
Sequence: TSSWVAGSGSSRPTHKDTADSENSDIQSLLSLTSEEYTDDIPLLKEA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length302
- Mass (Da)31,978
- Last updated2003-03-01 v1
- ChecksumA2360FDC71B69F23
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8C0M5 | Q8C0M5_MOUSE | Susd6 | 323 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 207-222 | Polar residues | ||||
Sequence: GRNMPREQQLQGQEAC |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK054203 EMBL· GenBank· DDBJ | BAC35691.1 EMBL· GenBank· DDBJ | mRNA | ||
AK161132 EMBL· GenBank· DDBJ | BAE36207.1 EMBL· GenBank· DDBJ | mRNA | ||
AC127337 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466590 EMBL· GenBank· DDBJ | EDL02681.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC040401 EMBL· GenBank· DDBJ | AAH40401.1 EMBL· GenBank· DDBJ | mRNA |