Q8BGE4 · SUSD6_MOUSE

  • Protein
    Sushi domain-containing protein 6
  • Gene
    Susd6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (By similarity).
Plays a role in preventing tumor onset (PubMed:24652652).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Biological ProcessDNA damage response

Names & Taxonomy

Protein names

  • Recommended name
    Sushi domain-containing protein 6
  • Alternative names
    • Drago

Gene names

    • Name
      Susd6
    • Synonyms
      Kiaa0247

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BGE4

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane120-140Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Mice are viable and fertile and do not show any notable developmental defect or spontaneous tumor development within 2 years. SUSD6 and TP53 double knockout mice show an increase in tumor development and a decrease in lifespan compared to TP53 knockout mice carrying wild-type SUSD6 (PubMed:24652652).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-39
ChainPRO_000043222340-302Sushi domain-containing protein 6
Disulfide bond42↔89
Disulfide bond74↔102

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain40-104Sushi
Region202-241Disordered
Compositional bias207-222Polar residues
Region256-302Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    302
  • Mass (Da)
    31,978
  • Last updated
    2003-03-01 v1
  • Checksum
    A2360FDC71B69F23
MCHGKIAPKSSSEFVVTSVGHGVFLQLVILCALLGDGLASVCPLPPEPENGGYICHPRPCKDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWTPAMEVSCHLIEDKETHALGVPALSIVASTASSVALILLLVVLFVLLQPKLKSFHHSRREQGVSGDQVSIMVDGVQVALPSYEEAVYGSSGHCMPPADPRVQIVLSEGSAPSGRNMPREQQLQGQEACSSAGGEDEAPGHSGLCEAWGSQGSETVMVHQATTSSWVAGSGSSRPTHKDTADSENSDIQSLLSLTSEEYTDDIPLLKEA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q8C0M5Q8C0M5_MOUSESusd6323

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias207-222Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK054203
EMBL· GenBank· DDBJ
BAC35691.1
EMBL· GenBank· DDBJ
mRNA
AK161132
EMBL· GenBank· DDBJ
BAE36207.1
EMBL· GenBank· DDBJ
mRNA
AC127337
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466590
EMBL· GenBank· DDBJ
EDL02681.1
EMBL· GenBank· DDBJ
Genomic DNA
BC040401
EMBL· GenBank· DDBJ
AAH40401.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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