Q8BGC3 · MOT12_MOUSE

  • Protein
    Monocarboxylate transporter 12
  • Gene
    Slc16a12
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na+, Cl-, or pH. Contributes to the process of creatine biosynthesis and distribution.

Catalytic activity

Activity regulation

Creatine uptake is inhibited by carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and by valinomycin.

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functioncreatine transmembrane transporter activity
Molecular Functionmonocarboxylic acid transmembrane transporter activity
Molecular Functionuniporter activity
Biological Processcreatine transmembrane transport
Biological Processcreatinine metabolic process

Names & Taxonomy

Protein names

  • Recommended name
    Monocarboxylate transporter 12
  • Short names
    MCT 12
  • Alternative names
    • Solute carrier family 16 member 12

Gene names

    • Name
      Slc16a12
    • Synonyms
      Mct12

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BGC3
  • Secondary accessions
    • Q14CF9
    • Q14DR7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein
Note: Interaction with isoform 2 of BSG is required for its localization to the plasma membrane.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-9Cytoplasmic
Transmembrane10-30Helical
Transmembrane58-78Helical
Transmembrane86-106Helical
Transmembrane115-135Helical
Transmembrane148-168Helical
Transmembrane177-197Helical
Transmembrane253-273Helical
Transmembrane289-309Helical
Transmembrane320-340Helical
Transmembrane353-373Helical
Transmembrane383-403Helical
Transmembrane410-430Helical
Topological domain431-486Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002866761-486Monocarboxylate transporter 12

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in the lung, liver, kidney, and pancreas (PubMed:26376857).
Expressed in eye lens

Developmental stage

Expressed in lens at P1 and P7 (PubMed:21778275).
The expression levels are higher than in adult lens (PubMed:21778275).
Detected in the basolateral membrane of the lens epithelium, with strong staining at equatorial epithelium, and in differentiating secondary fiber cells at P1 (at protein level) (PubMed:21778275).

Gene expression databases

Interaction

Subunit

Interacts with isoform 2 of BSG; this interaction is required for its localization to the plasma membrane.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    486
  • Mass (Da)
    53,152
  • Last updated
    2003-03-01 v1
  • Checksum
    AA3CC9951FB28247
MTKITRVSLASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNHNRESQREDCKQASPYSPLTKECTETRLCCSLQQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKRMKRTQVPFPVKDSDPKLQLWTNGSVAYSVARELDQKDEEPLPKARSGCNLT

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict234in Ref. 2; AAI13804/AAI11903
Sequence conflict293in Ref. 2; AAI13804

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK028284
EMBL· GenBank· DDBJ
BAC25857.1
EMBL· GenBank· DDBJ
mRNA
AK029076
EMBL· GenBank· DDBJ
BAC26279.1
EMBL· GenBank· DDBJ
mRNA
BC111902
EMBL· GenBank· DDBJ
AAI11903.1
EMBL· GenBank· DDBJ
mRNA
BC113803
EMBL· GenBank· DDBJ
AAI13804.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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