Q8BG67 · EFR3A_MOUSE

  • Protein
    Protein EFR3 homolog A
  • Gene
    Efr3a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcornified envelope
Cellular Componentcytosol
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpresynapse
Molecular Functionprotein homodimerization activity
Biological Processcell-cell adhesion
Biological Processprotein localization to plasma membrane
Biological Processsynaptic vesicle priming

Names & Taxonomy

Protein names

  • Recommended name
    Protein EFR3 homolog A
  • Alternative names
    • Protein EFR3-like

Gene names

    • Name
      Efr3a
    • Synonyms
      Kiaa0143

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BG67
  • Secondary accessions
    • Q6ZQI4
    • Q8BXQ7
    • Q8C0Q0
    • Q922I2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor
Cytoplasm, cytosol
Note: Palmitoylation anchors the protein to the plasma membrane. A small amount is observed in the cytosol.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002707661-819Protein EFR3 homolog A
Modified residue360Phosphoserine
Modified residue363Phosphoserine
Modified residue420Phosphoserine
Modified residue692Phosphoserine

Post-translational modification

Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed (PubMed:25380825).
Expressed in neurons of the superior olivary complex of the auditory brainstem. Also expressed at lower levels in the cochlear nucleus, the lateral leminiscal nuclei and the inferior collicus (PubMed:15363888).

Induction

Expression is reduced in animals with impaired hearing.

Gene expression databases

Interaction

Subunit

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the EFR3 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8BG67-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    819
  • Mass (Da)
    92,613
  • Last updated
    2003-03-01 v1
  • Checksum
    BF3BCD87C508CD1A
MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGAYLAERLSRDVVRHRSGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRLGPPSSPSAADKEENPAVLAESCFRELLGRATFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARRKDSPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRLSVELEANDSQKGSVGSVTVSSKDNDEKIVQNAVIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLSMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIETRTMEAPYFLPEHIFRDKCMLPKSLEKHDKNLYFLTNKIAESLGGSGYSVERLTVPYVPQVTDEDRLSRRKSIVDTVSIQVDILSNSVPSDDVVSNTEEITFEALKKAIDTNGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTVTSGHTQYQSVPVYEMKFPDLCVY

Q8BG67-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 786-819: PPPSPSGTLTVTSGHTQYQSVPVYEMKFPDLCVY → QRRESMLYKTEAEPCYTQPMAWGQRRIKEKYKAVVK

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I3BR57A0A2I3BR57_MOUSEEfr3a112
Q8BWC5Q8BWC5_MOUSEEfr3a174
G3UX01G3UX01_MOUSEEfr3a41
A0A1D5RLL3A0A1D5RLL3_MOUSEEfr3a846

Sequence caution

The sequence BAC97875.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict70in Ref. 3; BAC31942
Sequence conflict364in Ref. 4; AAH07482
Sequence conflict585in Ref. 3; BAC31942
Sequence conflict693in Ref. 3; BAC26768
Alternative sequenceVSP_022219786-819in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB158474
EMBL· GenBank· DDBJ
BAD52086.1
EMBL· GenBank· DDBJ
mRNA
AK129065
EMBL· GenBank· DDBJ
BAC97875.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK030074
EMBL· GenBank· DDBJ
BAC26768.1
EMBL· GenBank· DDBJ
mRNA
AK032461
EMBL· GenBank· DDBJ
BAC27881.1
EMBL· GenBank· DDBJ
mRNA
AK044000
EMBL· GenBank· DDBJ
BAC31732.1
EMBL· GenBank· DDBJ
mRNA
AK044475
EMBL· GenBank· DDBJ
BAC31942.1
EMBL· GenBank· DDBJ
mRNA
AK161250
EMBL· GenBank· DDBJ
BAE36269.1
EMBL· GenBank· DDBJ
mRNA
BC007482
EMBL· GenBank· DDBJ
AAH07482.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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