Q8BFZ6 · IDI2_MOUSE
- ProteinIsopentenyl-diphosphate delta-isomerase 2
- GeneIdi2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Catalytic activity
- isopentenyl diphosphate = dimethylallyl diphosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 36 | substrate | ||||
Sequence: K | ||||||
Binding site | 40 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 51 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 70 | substrate | ||||
Sequence: R | ||||||
Binding site | 74 | substrate | ||||
Sequence: K | ||||||
Active site | 86 | |||||
Sequence: S | ||||||
Binding site | 87 | substrate | ||||
Sequence: S | ||||||
Binding site | 146 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 148 | |||||
Sequence: E | ||||||
Binding site | 148 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | peroxisome | |
Molecular Function | isopentenyl-diphosphate delta-isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | dimethylallyl diphosphate biosynthetic process | |
Biological Process | isopentenyl diphosphate biosynthetic process | |
Biological Process | isopentenyl diphosphate metabolic process | |
Biological Process | negative regulation of cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIsopentenyl-diphosphate delta-isomerase 2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BFZ6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000420867 | 1-227 | Isopentenyl-diphosphate delta-isomerase 2 | |||
Sequence: MFQASKTHLDELQLKRLEEMCIVIDKQDQIIGADTKKNCHLMENINKGLLHRAFSVVLFNMKNELLVQQRADAKYTFPGHFTDSCSSHPLYVPEELEEKDALGVRRAALRRLQAELGISQDQISIKDIIFMTRKYHKCQSDAIWGEHEIGYLLLVRKDLMLNPDTREVRRCCYMSQKDVQELLDREARGEEKITPWFRSMVEDFLFSWWPHLEDVSSFVEPDKIYGL |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-199 | Nudix hydrolase | ||||
Sequence: LLHRAFSVVLFNMKNELLVQQRADAKYTFPGHFTDSCSSHPLYVPEELEEKDALGVRRAALRRLQAELGISQDQISIKDIIFMTRKYHKCQSDAIWGEHEIGYLLLVRKDLMLNPDTREVRRCCYMSQKDVQELLDREARGEEKITPWFRS | ||||||
Motif | 225-227 | Microbody targeting signal | ||||
Sequence: YGL |
Sequence similarities
Belongs to the IPP isomerase type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)26,665
- Last updated2003-03-01 v1
- ChecksumDACEA662BA4209A0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 20 | in Ref. 4; AAH99586 | ||||
Sequence: M → I | ||||||
Sequence conflict | 186 | in Ref. 4; AAH99586 | ||||
Sequence: E → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY263178 EMBL· GenBank· DDBJ | AAP21674.1 EMBL· GenBank· DDBJ | mRNA | ||
AK029364 EMBL· GenBank· DDBJ | BAC26418.1 EMBL· GenBank· DDBJ | mRNA | ||
AK081319 EMBL· GenBank· DDBJ | BAC38194.1 EMBL· GenBank· DDBJ | mRNA | ||
AC124732 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC099586 EMBL· GenBank· DDBJ | AAH99586.1 EMBL· GenBank· DDBJ | mRNA | ||
BC125310 EMBL· GenBank· DDBJ | AAI25311.1 EMBL· GenBank· DDBJ | mRNA | ||
BC138100 EMBL· GenBank· DDBJ | AAI38101.1 EMBL· GenBank· DDBJ | mRNA |