Q8BFQ3 · OGR1_MOUSE

  • Protein
    Ovarian cancer G-protein coupled receptor 1
  • Gene
    Gpr68
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity
Biological Processcellular response to pH
Biological Processinsulin secretion
Biological Processmonocyte differentiation
Biological Processnegative regulation of monocyte differentiation
Biological Processosteoclast development
Biological Processpositive regulation of insulin secretion
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processpositive regulation of osteoclast development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ovarian cancer G-protein coupled receptor 1
  • Alternative names
    • G-protein coupled receptor 68
    • Sphingosylphosphorylcholine receptor

Gene names

    • Name
      Gpr68
    • Synonyms
      Ogr1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8BFQ3
  • Secondary accessions
    • Q148P7
    • Q3U1L3
    • Q80T34

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-21Extracellular
Transmembrane22-46Helical; Name=1
Topological domain47-58Cytoplasmic
Transmembrane59-80Helical; Name=2
Topological domain81-95Extracellular
Transmembrane96-117Helical; Name=3
Topological domain118-136Cytoplasmic
Transmembrane137-158Helical; Name=4
Topological domain159-183Extracellular
Transmembrane184-205Helical; Name=5
Topological domain206-228Cytoplasmic
Transmembrane229-249Helical; Name=6
Topological domain250-263Extracellular
Transmembrane264-284Helical; Name=7
Topological domain285-365Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Mice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000701141-365Ovarian cancer G-protein coupled receptor 1
Glycosylation3N-linked (GlcNAc...) asparagine
Glycosylation8N-linked (GlcNAc...) asparagine
Disulfide bond94↔172

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    41,209
  • Last updated
    2003-03-01 v1
  • Checksum
    FD36FFB064D9E349
MGNITTENSSLSCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDDWSHGDLSCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHKEVIEDEDQHRVCFEHYPIQAWQRSINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWERNCEFAKSIFNVYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPSSLGVGGPSTVGLA

Sequence caution

The sequence AAI18035.2 differs from that shown. Reason: Erroneous initiation
The sequence AAI18045.2 differs from that shown. Reason: Erroneous initiation
The sequence BAC29521.1 differs from that shown. Reason: Erroneous initiation
The sequence BAC39863.1 differs from that shown. Reason: Erroneous initiation
The sequence BAE33483.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK036659
EMBL· GenBank· DDBJ
BAC29521.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK087410
EMBL· GenBank· DDBJ
BAC39863.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK155886
EMBL· GenBank· DDBJ
BAE33483.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC118034
EMBL· GenBank· DDBJ
AAI18035.2
EMBL· GenBank· DDBJ
mRNA Different initiation
BC118044
EMBL· GenBank· DDBJ
AAI18045.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AY255616
EMBL· GenBank· DDBJ
AAO85128.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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