Q8BFQ3 · OGR1_MOUSE
- ProteinOvarian cancer G-protein coupled receptor 1
- GeneGpr68
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids365 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | cellular response to pH | |
Biological Process | insulin secretion | |
Biological Process | monocyte differentiation | |
Biological Process | negative regulation of monocyte differentiation | |
Biological Process | osteoclast development | |
Biological Process | positive regulation of insulin secretion | |
Biological Process | positive regulation of insulin secretion involved in cellular response to glucose stimulus | |
Biological Process | positive regulation of osteoclast development |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOvarian cancer G-protein coupled receptor 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8BFQ3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-21 | Extracellular | ||||
Sequence: MGNITTENSSLSCPIDHTIHQ | ||||||
Transmembrane | 22-46 | Helical; Name=1 | ||||
Sequence: TLAPVVYVTVLVVGFPANCLSLYFG | ||||||
Topological domain | 47-58 | Cytoplasmic | ||||
Sequence: YLQIKARNELGV | ||||||
Transmembrane | 59-80 | Helical; Name=2 | ||||
Sequence: YLCNLTIADLFYICSLPFWLQY | ||||||
Topological domain | 81-95 | Extracellular | ||||
Sequence: VLQHDDWSHGDLSCQ | ||||||
Transmembrane | 96-117 | Helical; Name=3 | ||||
Sequence: VCGILLYENIYISVGFLCCISI | ||||||
Topological domain | 118-136 | Cytoplasmic | ||||
Sequence: DRYLAVAHPFRFHQFRTLK | ||||||
Transmembrane | 137-158 | Helical; Name=4 | ||||
Sequence: AAVGVSVLIWAKELLTSIYFLN | ||||||
Topological domain | 159-183 | Extracellular | ||||
Sequence: HKEVIEDEDQHRVCFEHYPIQAWQR | ||||||
Transmembrane | 184-205 | Helical; Name=5 | ||||
Sequence: SINYYRFLVGFLFPICLLLASY | ||||||
Topological domain | 206-228 | Cytoplasmic | ||||
Sequence: QGILRAVRRSHGTQKSRKDQIQR | ||||||
Transmembrane | 229-249 | Helical; Name=6 | ||||
Sequence: LVLSTVVIFLACFLPYHVLLL | ||||||
Topological domain | 250-263 | Extracellular | ||||
Sequence: VRSLWERNCEFAKS | ||||||
Transmembrane | 264-284 | Helical; Name=7 | ||||
Sequence: IFNVYHFSLLLTSFNCVADPV | ||||||
Topological domain | 285-365 | Cytoplasmic | ||||
Sequence: LYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPSSLGVGGPSTVGLA |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070114 | 1-365 | Ovarian cancer G-protein coupled receptor 1 | |||
Sequence: MGNITTENSSLSCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDDWSHGDLSCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHKEVIEDEDQHRVCFEHYPIQAWQRSINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWERNCEFAKSIFNVYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPSSLGVGGPSTVGLA | ||||||
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 8 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 94↔172 | |||||
Sequence: CQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHKEVIEDEDQHRVC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)41,209
- Last updated2003-03-01 v1
- ChecksumFD36FFB064D9E349
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK036659 EMBL· GenBank· DDBJ | BAC29521.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK087410 EMBL· GenBank· DDBJ | BAC39863.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK155886 EMBL· GenBank· DDBJ | BAE33483.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC118034 EMBL· GenBank· DDBJ | AAI18035.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC118044 EMBL· GenBank· DDBJ | AAI18045.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AY255616 EMBL· GenBank· DDBJ | AAO85128.1 EMBL· GenBank· DDBJ | mRNA |