Q8BB23 · NCAP_CVP67

Function

function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Features

Showing features for binding site.

144950100150200250300350400
TypeIDPosition(s)Description
Binding site106RNA (UniProtKB | ChEBI)
Binding site122RNA (UniProtKB | ChEBI)
Binding site164RNA (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endoplasmic reticulum-Golgi intermediate compartment
Cellular Componenthost cell Golgi apparatus
Cellular Componentribonucleoprotein complex
Cellular Componentviral nucleocapsid
Molecular FunctionRNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoprotein
  • Alternative names
    • Nucleocapsid protein
      (NC
      ; Protein N
      )

Gene names

    • Name
      N

Organism names

Accessions

  • Primary accession
    Q8BB23

Proteomes

Subcellular Location

Virion
Host Golgi apparatus
Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001060111-449Nucleoprotein
Modified residue167Phosphoserine; by host
Modified residue174Phosphothreonine; by host
Modified residue191Phosphoserine; by host
Modified residue391Phosphoserine; by host
Modified residue424Phosphoserine; by host
Modified residue428Phosphothreonine; by host

Post-translational modification

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues.

Keywords

Interaction

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-55Disordered
Region52-194RNA-binding
Domain61-190CoV N NTD
Region158-231Disordered
Compositional bias191-231Polar residues
Domain259-384CoV N CTD
Region266-297Disordered
Region266-385Dimerization
Compositional bias273-290Polar residues
Compositional bias387-422Polar residues
Region387-449Disordered
Compositional bias423-449Basic and acidic residues

Sequence similarities

Belongs to the betacoronavirus nucleocapsid protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    49,514
  • Last updated
    2003-03-01 v1
  • Checksum
    A9C486B39831F733
MSFTPGKQSSSRASSGNRSGNGILKWADQSDQSRNVQTRGRRVQSKQTATSQQPSGGTVVPYYSWFSGITQFQKGKEFEFAEGQGVPIAPGVPSTEAKGYWYRHNRRSFKTADGNQRQLLPRWYFYYLGTGPHAKDQYGTDIDGVFWVASNQADINTPADIVDRDPSSDEAIPTRFPPGTVLPQGYYIEGSGRSAPNSRSTSRAPNRAPSAGSRSRANSGNRTSTPGVTPDMADQIASLVLAKLGKDATKPQQVTKQTAKEVRQKILNKPRQKRSPNKQCTVQQCFGKRGPNQNFGGGEMLKLGTSDPQFPILAELAPTAGAFFFGSRLELAKVQNLSGNPDEPQKDVYELRYNGAIRFDSTLSGFETIMKVLNQNLNAYQHQEDGMMNISPKPQRQRGQKNGQVENDNVSVAAPKSRVQQNKSRELTAEDISLLKKMDEPYTEDTSEI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias191-231Polar residues
Compositional bias273-290Polar residues
Compositional bias387-422Polar residues
Compositional bias423-449Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY078417
EMBL· GenBank· DDBJ
AAL80036.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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