Q8AZK7 · EBNA5_EBVB9
- ProteinEpstein-Barr nuclear antigen leader protein
- GeneEBNA-LP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids506 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays an important role in the establishment of B-cell immortalization by acting as an EBNA2 coactivator. This transcriptional activation preferentially enhances the expression of the major viral protein LMP1. The interaction between EBNA-LP and host SP100 correlates with coactivation of EBNA2 and the relocalization of SP100 from PML nuclear bodies into nucleoplasm.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Cellular Component | host cell PML body | |
Molecular Function | transcription coactivator activity | |
Biological Process | DNA-templated viral transcription | |
Biological Process | symbiont-mediated disruption of host cell PML body |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEpstein-Barr nuclear antigen leader protein
- Short namesEBNA-LP; EBV nuclear antigen leader protein
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Gammaherpesvirinae > Lymphocryptovirus > Lymphocryptovirus humangamma4 > Epstein-Barr virus (strain GD1)
- Virus hosts
Accessions
- Primary accessionQ8AZK7
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 35 | 95% loss of phosphorylation. | ||||
Sequence: S → A |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000376060 | 1-506 | Epstein-Barr nuclear antigen leader protein | |||
Sequence: MGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPLRPRPRPPARSLREWLLRIRDHFEPPTVTTQRQSVYIEEEEDED | ||||||
Modified residue | 35 | Phosphoserine; by host | ||||
Sequence: S |
Post-translational modification
Phosphorylated by the cellular protein kinase cdc2.
Keywords
- PTM
PTM databases
Interaction
Subunit
Homooligomer. Interacts with host SP100; this interaction is important for EBNA-LP coactivator activity. Interacts with host HAX1, ERR1 and HSPA2. Interacts with host PRKDC and AKAP8L; these interactions modulate the coactivator function of EBNA-LP.
Binary interactions
Protein-protein interaction databases
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-470 | Disordered | ||||
Sequence: MGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPLRPRPRPP | ||||||
Compositional bias | 35-54 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 101-120 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 167-186 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 233-252 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 299-318 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 365-384 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 431-450 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Region | 485-506 | Disordered | ||||
Sequence: FEPPTVTTQRQSVYIEEEEDED |
Sequence similarities
Belongs to the lymphocryptovirus EBNA-LP family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length506
- Mass (Da)54,739
- Last updated2003-03-01 v1
- ChecksumCD2C6C3B737AC1E9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 35-54 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 101-120 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 167-186 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 233-252 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 299-318 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 365-384 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ | ||||||
Compositional bias | 431-450 | Basic and acidic residues | ||||
Sequence: SPTRGGQEPRRVRRRVLVQQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
V01555 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJ507799 EMBL· GenBank· DDBJ | CAD53387.1 EMBL· GenBank· DDBJ | Genomic DNA |