Q8AXX8 · SOX10_XENLA
- ProteinTranscription factor Sox-10
- Genesox10
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids446 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox9 to induce neural crest progenitors. Acts downstream of wnt-signaling at the neural plate border. Involved in the specification of neural crest progenitors fated to form the pigment cell lineage.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 98-166 | HMG box | ||||
Sequence: VKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLRMQHKKDHPDYK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | enzyme binding | |
Biological Process | central nervous system myelination | |
Biological Process | melanocyte differentiation | |
Biological Process | neural crest formation | |
Biological Process | oligodendrocyte development | |
Biological Process | oligodendrocyte differentiation | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranscription factor Sox-10
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ8AXX8
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Loss of neural crest precursors. Also an increase in apoptosis and a decrease in cell proliferation in the neural fold.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 52 | Eliminates one of two sumoylated products. Abolishes interaction with sumoylation factors. | ||||
Sequence: K → R | ||||||
Mutagenesis | 341 | Eliminates one of two sumoylated products. | ||||
Sequence: K → R |
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000376861 | 1-446 | Transcription factor Sox-10 | |||
Sequence: MSDDQSLSEVEMSPVGSEDPSLTPDPLPPHAHSSPDDDDDDDEEEEEETKVKKEQDSEDERFPVCIREAVSQVLNGYDWTLVPMPVRVNGGSKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKPSPGEGDGSSEAEGGAASIQAHYKNSHLDHRHGSPMSDGNSEHSTGQSHGPPTPPTTPKTELQAGKSDGKRDGSHALREGGKPQIDFGNVDIGEISHDVMSNMETFDVNEFDQYLPPNGHAGHPSHIGGYTSSYGLTGALAAGPSAWALAKQHSQTVADSKAQVKTESSSTSHYTEQPSTSQLTYTSLGLPHYGSAFPSISRPQFDYADHQPSSSYYSHSAQASSLYSAFSYMGPPQRPLYTAISDPPSVAQSHSPTHWEQPVYTTLSRP | ||||||
Cross-link | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||||
Sequence: K | ||||||
Cross-link | 341 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||||
Sequence: K |
Post-translational modification
Sumoylated.
Keywords
- PTM
Expression
Tissue specificity
First expressed at stages 13/14 at the lateral edges of the neural plate, in the neural crest forming region. By stage 22, neural crest cells migrate in the cranial region and strong expression is seen in the crest cells that populate the branchial arches as well as those migrating in the frontonasal region. Also strongly expressed in the trunk neural crest. Expression in the otic vesicle begins around stage 25 and persists until at least stage 40. At stage 30, expression is down-regulated in the cranial neural crest of the pharyngeal arches but persists in the trunk neural crest, in the otic vesicle and in discrete domains adjacent to the hindbrain. At stage 40, expression is restricted to the otic vesicle, differentiated pigment cells, and in several cranial ganglia.
Induction
By sox8, sox9 and snai1/snail, wnt-signaling and fgf-signaling in the neural crest-forming region.
Gene expression databases
Interaction
Subunit
Interacts with the sumoylation factors ube2i/ubc9 and sumo1.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-60 | Disordered | ||||
Sequence: MSDDQSLSEVEMSPVGSEDPSLTPDPLPPHAHSSPDDDDDDDEEEEEETKVKKEQDSEDE | ||||||
Region | 56-96 | Dimerization (DIM) | ||||
Sequence: DSEDERFPVCIREAVSQVLNGYDWTLVPMPVRVNGGSKSKP | ||||||
Compositional bias | 153-178 | Basic and acidic residues | ||||
Sequence: RLRMQHKKDHPDYKYQPRRRKNGKPS | ||||||
Region | 153-191 | Disordered | ||||
Sequence: RLRMQHKKDHPDYKYQPRRRKNGKPSPGEGDGSSEAEGG | ||||||
Region | 203-264 | Disordered | ||||
Sequence: HLDHRHGSPMSDGNSEHSTGQSHGPPTPPTTPKTELQAGKSDGKRDGSHALREGGKPQIDFG | ||||||
Region | 217-303 | Transactivation domain (TAM) | ||||
Sequence: SEHSTGQSHGPPTPPTTPKTELQAGKSDGKRDGSHALREGGKPQIDFGNVDIGEISHDVMSNMETFDVNEFDQYLPPNGHAGHPSHI | ||||||
Compositional bias | 240-255 | Basic and acidic residues | ||||
Sequence: AGKSDGKRDGSHALRE | ||||||
Region | 337-446 | Transactivation domain (TAC) | ||||
Sequence: KAQVKTESSSTSHYTEQPSTSQLTYTSLGLPHYGSAFPSISRPQFDYADHQPSSSYYSHSAQASSLYSAFSYMGPPQRPLYTAISDPPSVAQSHSPTHWEQPVYTTLSRP | ||||||
Region | 421-446 | Disordered | ||||
Sequence: SDPPSVAQSHSPTHWEQPVYTTLSRP | ||||||
Compositional bias | 422-446 | Polar residues | ||||
Sequence: DPPSVAQSHSPTHWEQPVYTTLSRP |
Domain
The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length446
- Mass (Da)49,098
- Last updated2003-03-01 v1
- ChecksumB7F13C68F2854443
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 36 | in Ref. 3; AAI70062 | ||||
Sequence: D → DDD | ||||||
Compositional bias | 153-178 | Basic and acidic residues | ||||
Sequence: RLRMQHKKDHPDYKYQPRRRKNGKPS | ||||||
Compositional bias | 240-255 | Basic and acidic residues | ||||
Sequence: AGKSDGKRDGSHALRE | ||||||
Compositional bias | 422-446 | Polar residues | ||||
Sequence: DPPSVAQSHSPTHWEQPVYTTLSRP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY149116 EMBL· GenBank· DDBJ | AAN62483.1 EMBL· GenBank· DDBJ | mRNA | ||
AY157667 EMBL· GenBank· DDBJ | AAO13216.1 EMBL· GenBank· DDBJ | mRNA | ||
BC170062 EMBL· GenBank· DDBJ | AAI70062.1 EMBL· GenBank· DDBJ | mRNA |