Q8AXX8 · SOX10_XENLA

Function

function

Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox9 to induce neural crest progenitors. Acts downstream of wnt-signaling at the neural plate border. Involved in the specification of neural crest progenitors fated to form the pigment cell lineage.

Caution

Although PubMed:12812785 report induction by snai2/slug, PubMed:12885557 report that sox10 lies in between snai1/snail and snai2/slug in the complex sequence of inductive events required for neural crest formation.

Features

Showing features for dna binding.

144650100150200250300350400
TypeIDPosition(s)Description
DNA binding98-166HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionenzyme binding
Biological Processcentral nervous system myelination
Biological Processmelanocyte differentiation
Biological Processneural crest formation
Biological Processoligodendrocyte development
Biological Processoligodendrocyte differentiation
Biological Processpositive regulation of DNA-templated transcription
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor Sox-10
  • Alternative names
    • SRY (sex determining region Y)-box 10

Gene names

    • Name
      sox10

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q8AXX8
  • Secondary accessions
    • B7ZR69

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Loss of neural crest precursors. Also an increase in apoptosis and a decrease in cell proliferation in the neural fold.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis52Eliminates one of two sumoylated products. Abolishes interaction with sumoylation factors.
Mutagenesis341Eliminates one of two sumoylated products.

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003768611-446Transcription factor Sox-10
Cross-link52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-link341Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modification

Sumoylated.

Keywords

Expression

Tissue specificity

First expressed at stages 13/14 at the lateral edges of the neural plate, in the neural crest forming region. By stage 22, neural crest cells migrate in the cranial region and strong expression is seen in the crest cells that populate the branchial arches as well as those migrating in the frontonasal region. Also strongly expressed in the trunk neural crest. Expression in the otic vesicle begins around stage 25 and persists until at least stage 40. At stage 30, expression is down-regulated in the cranial neural crest of the pharyngeal arches but persists in the trunk neural crest, in the otic vesicle and in discrete domains adjacent to the hindbrain. At stage 40, expression is restricted to the otic vesicle, differentiated pigment cells, and in several cranial ganglia.

Induction

By sox8, sox9 and snai1/snail, wnt-signaling and fgf-signaling in the neural crest-forming region.

Gene expression databases

    • 398422Expressed in internal ear and 10 other cell types or tissues

Interaction

Subunit

Interacts with the sumoylation factors ube2i/ubc9 and sumo1.

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-60Disordered
Region56-96Dimerization (DIM)
Compositional bias153-178Basic and acidic residues
Region153-191Disordered
Region203-264Disordered
Region217-303Transactivation domain (TAM)
Compositional bias240-255Basic and acidic residues
Region337-446Transactivation domain (TAC)
Region421-446Disordered
Compositional bias422-446Polar residues

Domain

The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    49,098
  • Last updated
    2003-03-01 v1
  • Checksum
    B7F13C68F2854443
MSDDQSLSEVEMSPVGSEDPSLTPDPLPPHAHSSPDDDDDDDEEEEEETKVKKEQDSEDERFPVCIREAVSQVLNGYDWTLVPMPVRVNGGSKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKPSPGEGDGSSEAEGGAASIQAHYKNSHLDHRHGSPMSDGNSEHSTGQSHGPPTPPTTPKTELQAGKSDGKRDGSHALREGGKPQIDFGNVDIGEISHDVMSNMETFDVNEFDQYLPPNGHAGHPSHIGGYTSSYGLTGALAAGPSAWALAKQHSQTVADSKAQVKTESSSTSHYTEQPSTSQLTYTSLGLPHYGSAFPSISRPQFDYADHQPSSSYYSHSAQASSLYSAFSYMGPPQRPLYTAISDPPSVAQSHSPTHWEQPVYTTLSRP

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict36in Ref. 3; AAI70062
Compositional bias153-178Basic and acidic residues
Compositional bias240-255Basic and acidic residues
Compositional bias422-446Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY149116
EMBL· GenBank· DDBJ
AAN62483.1
EMBL· GenBank· DDBJ
mRNA
AY157667
EMBL· GenBank· DDBJ
AAO13216.1
EMBL· GenBank· DDBJ
mRNA
BC170062
EMBL· GenBank· DDBJ
AAI70062.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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