Q8A6Z2 · Q8A6Z2_BACTN

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site624Mg2+ (UniProtKB | ChEBI)
Binding site663Mg2+ (UniProtKB | ChEBI)
Binding site667Mg2+ (UniProtKB | ChEBI)
Binding site828Mg2+ (UniProtKB | ChEBI)
Binding site830ATP (UniProtKB | ChEBI)
Active site1079Nucleophile
Active site1192
Active site1194

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • Ordered locus names
      BT_1733

Organism names

Accessions

  • Primary accession
    Q8A6Z2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-80Phosphoribosylformylglycinamidine synthase N-terminal
Domain122-171Phosphoribosylformylglycinamidine synthase linker
Domain380-534PurM-like C-terminal
Domain781-907PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,234
  • Mass (Da)
    136,487
  • Last updated
    2003-06-01 v1
  • Checksum
    346961FDC63518FF
MILFFRTPSKSVIAVESNHQLTPDESNKLCWLFGEAVTESEENLKGCFVGPRREMITPWSTNAVEITQNMGLEDILRIEEYFPVKDENADYDPMLQRMYKGLDQNVFTTNRQPEPIVSIEDLEAYNEKEGLALSKEEMDYLKKVENDLGRKLTDSEVFGFAQINSEHCRHKIFGGTFIIDGVEQESSLFQMIKKTTQENPNKIISAYKDNVAFAEGPVVEQFAPADHSKPDFFQVKDIKSVISLKAETHNFPTTVEPFNGASTGTGGEIRDRMGGGKGSWPIAGTAVYMTSYPRTDEGREWEDILPVRKWLYQTPEQILIKASNGASDFGNKFGQPLICGSVLTFEHTENNEVYGYDKVIMLAGGVGYGTQRDCLKGTPEAGNKVVVIGGDNYRIGLGGGSVSSVDTGRYSSGIELNAVQRANAEMQKRANNVVRALCEEDVNPVVSIHDHGSAGHVNCLSELVEECGGLIDMSKLPIGDKTLSAKEIIANESQERMGLLIKEEAIEHVRKIAERERAPMYVVGETTGDHRFSFQQADGVRPFDLAVEQMFGSSPKTYMIDKTVERHYEMPEYELPKLHEYLTNVLQLEAVACKDWLTNKVDRSVTGKVARQQCQGELQLPLSDCGVVALDYRGEKGIATSIGHAPQAALADPAAGSILSVSEALTNLVWAPMAEGMDSISLSANWMWPCRSQEGEDARLYTAVKALSDFCCALQINVPTGKDSLSMTQKYPNGEKVISPGTVIVSAGGEVSDVKKVVSPVLVNNEKTTLYHIDFSFDELKLGGSAFAQSLGKVGDDVPCVQDAEYFRDAFLAVQELVNKGLILAGHDISAGGLITTLLEMCFANVEGGMEISLDKMKEQDIIKILFAENPGIVIQISDKHKEEVKKILEDAGVGFVKLGKPTDERHILVSKGDATYQFGVDYMRDVWYSSSYLLDRKQSMNGCAKKRFENYKMQPVEFAFMPGFKGKLSQYGITPDRRTPSGVRAAIIREKGTNGEREMAYSLYLAGFDVKDVTMTDLISGRETLEDVNMIVYCGGFSNSDVLGSAKGWAGGFLFNPKAKEALDKFYAREDTLSLGICNGCQLMMELGLINPEHEKKGKMLHNDSHKFESTYVGLTIPTNRSVMFGSLSGSKLGIWVAHGEGKFSLPYDEDQYNVVAKYSYDEYPGNPNGSDYSIAGLASADGRHLAMMPHLERAIFPWQNGCYPADRKNSDQITPWIEAFVNARKWVEEKTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE015928
EMBL· GenBank· DDBJ
AAO76840.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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