Q89YT0 · END4_BACTN

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

127720406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Binding site109Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 2 (UniProtKB | ChEBI)
Binding site179Zn2+ 2 (UniProtKB | ChEBI)
Binding site182Zn2+ 3 (UniProtKB | ChEBI)
Binding site214Zn2+ 2 (UniProtKB | ChEBI)
Binding site227Zn2+ 3 (UniProtKB | ChEBI)
Binding site229Zn2+ 3 (UniProtKB | ChEBI)
Binding site259Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • Ordered locus names
      BT_4651

Organism names

Accessions

  • Primary accession
    Q89YT0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001908261-277Probable endonuclease 4

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    31,540
  • Last updated
    2003-06-01 v1
  • Checksum
    71319F89A904BE91
MKYIGAHVSASGGVEFAPVNAHEIGANAFALFTKNQRQWVSKPLKEENIRLFKENCTKYNFQTDYILPHDSYLINLGHPEEEGLEKSRAAFLDEMQRCEQLGLKLLNFHPGSHLNKISIEDCLALIAESINLTLEKTKGVTAVIENTAGQGSNLGSEFWQLRYIIDRVNDKSRVGICLDTCHTYTAGYDIVNDYDKVFDEFEKEVGFEYLRGMHLNDSKKELGSHVDRHDNIGQGLIGSAFFERLMKDSRFDNMPLILETPDESKWAEEIAWLRSVE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE015928
EMBL· GenBank· DDBJ
AAO79756.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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