Q89U93 · Q89U93_BRADU

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site38substrate
Site38Important for catalytic activity
Binding site269substrate
Site269Important for catalytic activity
Binding site364substrate
Binding site392substrate
Binding site469substrate
Binding site477substrate
Binding site481substrate
Binding site528substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • Name
      tktA

Organism names

Accessions

  • Primary accession
    Q89U93

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain361-533Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    671
  • Mass (Da)
    71,529
  • Last updated
    2003-06-01 v1
  • Checksum
    E290A66BE559EAFB
MMQLDASRMAHTQVDHSRMANAIRGLSMDAVEKAKSGHPGLPMGAADIATVLFTQFLKFDAAAPAWPDRDRFVLSAGHGSMLLYSLLYLTGNADMTLDQLKQFRQLGGLTPGHPENFHTKGIETTTGPLGQGISTAVGMALAEKMLAAEFGKKIVDHHTFVLASDGDLMEGVSQEAIAMAGHWKLNKLIVLYDDNGISIDGPTSIADSVDQVKRFKSAGWAAEKIDGHDQAAITAAITRAKKSNKPTLIACRTTIGFGAPHKAGTSKVHGEALGAEELKAAKENLGISLEPFSVPDDVLKAWRAAGSRGAAARQEWEGRLGELGSRKRAEFERRLRHERPASLAKAVRAYKKELLEKPLVAATRKSSEAVIEVIAGAMPMEFLAGSADLTGSNNNKAKSATAFSAKTPKGRFIHYGIREHGMAAAMNGIFLHGGFAPNGATFLVFTDYARPAMRLAALMGTGVVYVMTHDSIGLGEDGPTHQPVEHLAALRAIPNMRVFRPCDSIEVAECWELALNRIDGPTVLALTRQNLPQLRTTAPNDNPCAAGAYELVPAQGEAKATLFASGSEVEIAVAAQKQLAERGIPSRVVSVPSLELLLAQPEAKRAEIIGNAPVKVAIEAAVRWGWDAVIGQDGEFVGMHSFGASAPAKDLYKHFGITAEAAVNAVLKRVS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000040
EMBL· GenBank· DDBJ
BAC46789.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp