Q89AK2 · MFD_BUCBP

Function

function

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity).

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site181-188ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondamaged DNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription-repair-coupling factor
  • EC number
  • Short names
    TRCF

Gene names

    • Name
      mfd
    • Ordered locus names
      bbp_275

Organism names

Accessions

  • Primary accession
    Q89AK2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001021651-697Transcription-repair-coupling factor

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

Type
IDPosition(s)Description
Domain168-329Helicase ATP-binding
Motif282-285DEEH box
Domain350-504Helicase C-terminal

Sequence similarities

In the N-terminal section; belongs to the UvrB family.
In the C-terminal section; belongs to the helicase family. RecG subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    697
  • Mass (Da)
    80,419
  • Last updated
    2003-06-01 v1
  • Checksum
    DF4C7E23C4FADBE7
MLIKSLVQKNQVYFTNNSLDEKNICDLSKLKINQPIVHFEHGVGRYQGLTTVTTRNIKTECVVINYAQNSKLYVPITYLYLISRYIGTSKKDIPLHRLGNDLWNKEKKKANEKAYDSAAILLNIYSHRISQKGFSFKKHHTKYKIFCERFPFTLTPDQDSAINSVLSDMYKSTPMDRLVCGDVGFGKTEVAMRATFLAVCNQKQVAILVPTTLLAQQHFNNFTLRFKYWSTKIEILSRFQSETKCNEIINNVNIGNVHVLIGTHKILLKNLKWKNLGLLIVDEEHRFGVHHKEQIKLISNNIDVLTLTATPIPRTLNMAFVGIRDLSIIATPPKQRLIVKTFVREFSYTVIRKAILREILRGGQVYYIYNNVNKIERKKIELKKLVPEANIRIGHGQLRSTDLESIMNDFYHKRFNVLVCSTIIETGIDIPNVNTIIIENANNFGLAQLHQLRGRVGRSQHQAYAWLLVPSLKDIKSDAKKRIDAITSIESFGSCFELANRDLEIRGIGEILGNNQSGHITKIGFSLYMKLLMNAVRNIKNGYYKPLNDIINTYPKIELNVSNLLPDSYIKKVNHRLFFYNKIATSNNFLDLEKIRLTLCKNFGNLPNSGDYLIKIAKIRLISKKIGVKKIKSDVKGGYIEFFEDSKINIQNLLKEFKKEKNCWKFDTSNRLRFSKNFKNNSERIDWILNMLININN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016826
EMBL· GenBank· DDBJ
AAO27000.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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