Q89730 · GC_HHV2H

Function

function

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate (By similarity).
Also plays a role in host immune evasion by inhibiting the host complement cascade activation

Miscellaneous

There are seven external glycoproteins in HSV-1 and 2: gH, gB, gC, gG, gD, gI, and gE.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentvirion membrane
Biological Processadhesion receptor-mediated virion attachment to host cell
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host complement activation
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein C

Gene names

    • Name
      gC
    • Synonyms
      UL44

Organism names

Accessions

  • Primary accession
    Q89730
  • Secondary accessions
    • O12512

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain28-447Virion surface
Transmembrane448-468Helical
Topological domain469-480Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000003820128-480Envelope glycoprotein C
Glycosylation40N-linked (GlcNAc...) asparagine; by host
Glycosylation52N-linked (GlcNAc...) asparagine; by host
Disulfide bond96↔113
Glycosylation117N-linked (GlcNAc...) asparagine; by host
Glycosylation150N-linked (GlcNAc...) asparagine; by host
Glycosylation166N-linked (GlcNAc...) asparagine; by host
Disulfide bond255↔316
Glycosylation331N-linked (GlcNAc...) asparagine; by host
Disulfide bond355↔411
Disulfide bond359↔388

Keywords

PTM databases

Interaction

Subunit

Interacts with host complement component C3b; this interaction inhibits host immune response by disregulating complement cascade.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region30-101Disordered
Compositional bias33-55Polar residues
Region106-120Heparin-binding domain
Domain236-328Ig-like

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    480
  • Mass (Da)
    51,671
  • Last updated
    1996-11-01 v1
  • Checksum
    C145B4EFEF582B63
MALGRVGLAVGLWGLLWVGVVVVLANASPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKATKSKASTAKPAPPPKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTEFRLQIWRYATATDAEIGTAPSLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSVVGPLGRQRLIIEELTLETQGMYYWVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDPAQIHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTGDHAVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPDGIPVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAVVLAGTAVVYLTHASSVRYRRLR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias33-55Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z86099
EMBL· GenBank· DDBJ
CAB06730.1
EMBL· GenBank· DDBJ
Genomic DNA
U12179
EMBL· GenBank· DDBJ
AAB60551.1
EMBL· GenBank· DDBJ
Genomic DNA
U12177
EMBL· GenBank· DDBJ
AAB60550.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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