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Q88S37 · IOLE_LACPL

Function

function

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
glutathione (UniProtKB | Rhea| CHEBI:57925 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7.

GO annotations

AspectTerm
Molecular Functionmanganese ion binding
Molecular Functionmyo-inosose-2 dehydratase activity
Biological Processinositol catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosose dehydratase
  • EC number
  • Alternative names
    • 2-keto-myo-inositol dehydratase
      (2KMI dehydratase
      )

Gene names

    • Name
      iolE
    • Ordered locus names
      lp_3607

Organism names

Accessions

  • Primary accession
    Q88S37
  • Secondary accessions
    • F9ULG1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003523741-300Inosose dehydratase

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the IolE/MocC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    300
  • Mass (Da)
    33,881
  • Last updated
    2003-06-01 v1
  • MD5 Checksum
    28D37AA27693287906408CEDBCA0CB2B
MSSKAEKDIKWGIAPIGWRNDDIPSIGKDNNLQQLLSDIVVAGFQGTEVGGFFPGPEKLNYELKLRNLEIAGQWFSSYIIRDGIEKASEAFEKHCQYLKAINAPVAVVSEQTYTIQRSDTANIFKDKPYFTDKEWDEVCKGLNHYGEIAAKYGLKVAYHHHMGTGIQTKEETDRLMANTDPKLVGLLYDTGHIAVSDGDYMALLNAHIDRVVHVHFKDVRRSKEEECRAKGLTFQGSFLNGMFTVPGDGDLDFKPVYDKLIANNYKGWIVVEAEQDPSKANPLEMAQIAHRYIKQHLIEN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL935263
EMBL· GenBank· DDBJ
CCC80568.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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