Q88B49 · HEM6_PSESM

Function

function

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site93substrate
Binding site97a divalent metal cation (UniProtKB | ChEBI)
Active site107Proton donor
Binding site107a divalent metal cation (UniProtKB | ChEBI)
Binding site109-111substrate
Binding site146a divalent metal cation (UniProtKB | ChEBI)
Binding site176a divalent metal cation (UniProtKB | ChEBI)
Site176Important for dimerization
Binding site259-261substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncoproporphyrinogen oxidase activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxygen-dependent coproporphyrinogen-III oxidase
  • EC number
  • Short names
    CPO
    ; Coprogen oxidase
    ; Coproporphyrinogenase

Gene names

    • Name
      hemF
    • Ordered locus names
      PSPTO_0170

Organism names

Accessions

  • Primary accession
    Q88B49

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001099121-304Oxygen-dependent coproporphyrinogen-III oxidase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region241-276Important for dimerization

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    304
  • Mass (Da)
    34,501
  • Last updated
    2003-06-01 v1
  • Checksum
    4087748F13C31B72
MSTRTEAVKAYLLDLQDRICTALEQEDGNAHFVEDAWTRPAGGGGRTRVVENGAVIEKGGVNFSHVFGSNLPPSASAHRPELAGRGFEALGVSLVIHPHSPHVPTSHANVRFFIAEKEGEEPVWWFGGGFDLTPYYGVEEDCVHWHRVAERACAPFGDDVYPRYKAWCDSYFHLKHRDEPRGIGGLFFDDVNQWDFDTSFAFIRAIGDAFINAYLPIVRRRKAAAYTVQQREFQEFRRGRYVEFNLVYDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKAAPGSEEARLTDYFLTDRDWLADN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016853
EMBL· GenBank· DDBJ
AAO53724.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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