Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q884N3 · SPEE_PSESM

Function

function

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

Catalytic activity

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

Features

Showing features for binding site, active site.

128620406080100120140160180200220240260280
Type
IDPosition(s)Description
Binding site30S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site61spermidine (UniProtKB | ChEBI)
Binding site85spermidine (UniProtKB | ChEBI)
Binding site105S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site137-138S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Active site155Proton acceptor
Binding site155-158spermidine (UniProtKB | ChEBI)
Binding site162S-methyl-5'-thioadenosine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionspermidine synthase activity
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyamine aminopropyltransferase
  • Alternative names
    • Putrescine aminopropyltransferase
      (PAPT
      )
    • Spermidine synthase
      (SPDS
      ; SPDSY
      ) (EC:2.5.1.16
      ) . EC:2.5.1.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      speE
    • Ordered locus names
      PSPTO_2055

Organism names

Accessions

  • Primary accession
    Q884N3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001564991-286Polyamine aminopropyltransferase

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-235PABS

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    286
  • Mass (Da)
    32,055
  • Last updated
    2003-06-01 v1
  • MD5 Checksum
    898754F819E23978773FDF9CC6816C24
MSDYQETLYEGYGQRFRMEKMLHEVRTEHQHLVIFQNPRMGRVMALDGVIQTTEADEFIYHEMLTHVPILAHGAAKRVLIIGGGDGGMLREVAKHLTVEHITMVEIDATVVEMCKEFLPNHSSGAFDDSRLNLVIDDGMRFVATTEEKFDVIISDSTDPIGPGEVLFSENFYQACHRCLNEGGILVTQNGTPFMQLSGVQTTAGRMNGLFADWHFYQAAIPTYIGGAMTFAWGATDKSYRKLPLETLRQRFSGSGIVTRYYNPEVHIGAFALPQYVLHAVNKASND

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016853
EMBL· GenBank· DDBJ
AAO55573.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help