Q87Y79 · MAO1_PSESM
- ProteinNAD-dependent malic enzyme
- GenemaeA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids563 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (S)-malate + NAD+ = pyruvate + CO2 + NADH
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Divalent metal cations. Prefers magnesium or manganese.
Features
Showing features for active site, binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 101 | Proton donor | |||
Binding site | 154 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 172 | Proton acceptor | |||
Binding site | 243 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 244 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 267 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 267 | NAD+ (UniProtKB | ChEBI) | |||
Site | 267 | Important for activity | |||
Binding site | 416 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | malate dehydrogenase (decarboxylating) (NAD+) activity | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Molecular Function | oxaloacetate decarboxylase activity | |
Biological Process | malate metabolic process | |
Biological Process | pyruvate metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent malic enzyme
- EC number
- Short namesNAD-ME
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionQ87Y79
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000160225 | 1-563 | NAD-dependent malic enzyme | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length563
- Mass (Da)62,076
- Last updated2005-12-06 v2
- ChecksumD5C6DFEA1CFD11F1
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016853 EMBL· GenBank· DDBJ | AAO57390.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |