Q87WW1 · Q87WW1_PSESM

Function

function

APS kinase catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site31-38GTP (UniProtKB | ChEBI)
Binding site34GDP (UniProtKB | ChEBI)
Binding site36GDP (UniProtKB | ChEBI)
Binding site37GDP (UniProtKB | ChEBI)
Binding site38GDP (UniProtKB | ChEBI)
Binding site39GDP (UniProtKB | ChEBI)
Binding site83GDP (UniProtKB | ChEBI)
Binding site110-114GTP (UniProtKB | ChEBI)
Binding site165GDP (UniProtKB | ChEBI)
Binding site165-168GTP (UniProtKB | ChEBI)
Binding site166GDP (UniProtKB | ChEBI)
Binding site168GDP (UniProtKB | ChEBI)
Binding site205GDP (UniProtKB | ChEBI)
Binding site206GDP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionadenylylsulfate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionguanosine tetraphosphate binding
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processhydrogen sulfide biosynthetic process
Biological Processphosphorylation
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfate adenylyltransferase subunit 1
  • EC number
  • Alternative names
    • ATP-sulfurylase large subunit
    • Sulfate adenylate transferase
      (SAT
      )

Gene names

    • Name
      cysN
    • Synonyms
      cysN/C
    • Ordered locus names
      PSPTO_4432

Organism names

Accessions

  • Primary accession
    Q87WW1

Proteomes

Interaction

Subunit

Heterodimer composed of CysD, the smaller subunit, and CysN.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-241Tr-type G

Sequence similarities

In the C-terminal section; belongs to the APS kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    632
  • Mass (Da)
    69,053
  • Last updated
    2003-06-01 v1
  • Checksum
    4EE729FBD73B23E4
MSHQSDLISEDILAYLGQHERKEMLRFLTCGNVDDGKSTLIGRLLHDSKMIYEDHLEAITRDSKKSGTTGDDVDLALLVDGLQAEREQGITIDVAYRYFSTAKRKFIIADTPGHEQYTRNMATGASTCDLAIILVDARYGVQTQTRRHSYIASLLGIKHIVVAINKMDLNGFDERVFESIKADYLKFAEGIAFKPTTMAFVPMSALKGDNVVNKSERSPWYAGQSLMEILETVEIASDRNYTDLRFPVQYVNRPNLNFRGFAGTLASGIVHKGDEIVVLPSGKSSRVKSIVTFEGELEQAGPGQAVTLTMEDEIDISRGDLLVHADNVPQVSDAFDAMLVWMAEEPMLPGKKYDIKRATSYVPGSIASITHRVDVNTLEEGPASSLQLNEIGRVKVSLDAPIALDGYSSNRTTGAFIVIDRLTNGTVAAGMIIAKPVSGGGSHHHGELAHVSTEERAQRFGQQPATVLFSGLSGAGKSTLAYAVERKLFDMGRAVYVLDGQNLRHDLNKGLPQDRAGRTENWSRAAHVARQFNEAGLLTLAAFVAPDAEGRERAKALIGKERLVTVYVQASPAVCRERDPQGLYAADGDNIPGESFPYDVPLNADLVIDTQTLSVEESVKQVLDLLRGRGAI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016853
EMBL· GenBank· DDBJ
AAO57881.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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