Q87WP8 · Q87WP8_PSESM

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site194-201ATP (UniProtKB | ChEBI)
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site494Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • Ordered locus names
      PSPTO_4497

Organism names

Accessions

  • Primary accession
    Q87WP8

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane98-120Helical

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain186-325AAA+ ATPase
Compositional bias591-605Basic and acidic residues
Region591-634Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    634
  • Mass (Da)
    68,967
  • Last updated
    2003-06-01 v1
  • Checksum
    E041563F68E0FA53
MAKNLILWLIIAAVLVTVMNNFSSPNEPQNFNYSEFIQQVKDGKVEKVSVDGYVITGKRSDGDTFKTIRPNIPDNGLIGDLVSNNVVVEGKQPEQQSIWTQLLVASFPILVIIAVFMFFMRQMQGGAGGKGGPMSFGKSKARLLSEDQVKTTLADVAGCDEAKEEVGELVEFLRDPGKFQRLGGRIPRGVLMVGPPGTGKTLIAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKHAPCIIFIDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFEMNDGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDIRGREQILKVHMRKVPMGEDVNPGVIARGTPGFSGADLANLVNEASLFAARSGKRVVEMKEFELAKDKIMMGAERKSMVMSDKEKRNTAYHEAGHAIVGRLVPEHDPVYKVSIIPRGRALGVTMFLPEEDRYSLSKRALISQICSLYGGRIAEEMTLGFDGVTTGASNDIMRASQIARNMVTKWGLSEKLGPLMYSEDEDGGYLGRGGSQNSSVSGDTAKLIDSEVRSIIDHCYGTAKQLLTDNRDKLEAMADALMKYETIDADQIDDIMTGRPPREPRDWDGGSGTNGTPITPDPRPETPIGGPAAEH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias591-605Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016853
EMBL· GenBank· DDBJ
AAO57945.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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