Q87V15 · AROB_PSESM
- Protein3-dehydroquinate synthase
- GenearoB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids367 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 69-74 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 103-107 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 127-128 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 140 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 149 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 182 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 245 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 262 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate synthase
- EC number
- Short namesDHQS
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionQ87V15
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000140770 | 1-367 | 3-dehydroquinate synthase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length367
- Mass (Da)39,979
- Last updated2003-06-01 v1
- Checksum115906187046F42D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016853 EMBL· GenBank· DDBJ | AAO58553.1 EMBL· GenBank· DDBJ | Genomic DNA |