Q87BY8 · METE_XYLFT

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site16-195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1165-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site436-438L-homocysteine (UniProtKB | ChEBI)
Binding site436-438L-methionine (UniProtKB | ChEBI)
Binding site489L-homocysteine (UniProtKB | ChEBI)
Binding site489L-methionine (UniProtKB | ChEBI)
Binding site520-5215-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5665-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site604L-homocysteine (UniProtKB | ChEBI)
Binding site604L-methionine (UniProtKB | ChEBI)
Binding site6105-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site646Zn2+ (UniProtKB | ChEBI); catalytic
Binding site648Zn2+ (UniProtKB | ChEBI); catalytic
Binding site670Zn2+ (UniProtKB | ChEBI); catalytic
Active site699Proton donor
Binding site731Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      PD_1308

Organism names

Accessions

  • Primary accession
    Q87BY8

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000986811-7585-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Structure

Family & Domains

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    758
  • Mass (Da)
    85,748
  • Last updated
    2003-06-16 v1
  • Checksum
    985128BABD80E9F4
MTIVTNLGFPRIGARRELKRALESHWRGETDATQLQHTARELRARHWRLQRDAGVDLPPSNDFSLYDHVLDTAFLFDAIPQRYRGLVDADPLAGYFAMARGRQADNIDLHALEMTKWFDTNYHYLVPELHRDQHFALRGNKPIAEFEEALALGITTRPVLLGPVSFLLLSKTVDGSNRLDLLERLLPVYTQLLRQLQESGAEWVQIDEPTLVLDLDAQTQQAFRKAYAILNQGPRPKLLLTSYFGPLGDNLELALQLPADGLHIDLVRGTEQLDAVLNTLPAGRVLSAGLVNGRNIWRTDLDNALTMARYAQGHVGADRLWLAPSCSLLHVPVDLEQEKNLDADVRNWLAFAKQKLSELRVLADALDNKPEAETALTQTRQALEARRQSPKVHRPDVAQRLAALTPDTTRRNTAYPQRSQAQQHTLNLPAYPTTTIGSFPQTLEVREARAQFKSGKLSESDYEAFLKAETERCVRTQEEIGLDVLVHGEFERNDMVEYFGEQLDGFIFTKLGWVQSYGSRCVKPPIIYGDVVRPAPMTVTWSAYAQSLTDKPMKGMLTGPVTMLQWSFVRDDQERAQTCRQIALALRDEVQDLEKAGIKVIQIDEPAIREGLPLRRGEWADYLNWAVESFRIASSNVHDTTQIHTHMCYSEFNDIIEAVAALDADVISIETSRSRMELLDAFVKFRYPNAIGPGVYDIHSPRVPQEEEMVLLLKKARAVLPPEQLWVNPDCGLKTRGWKETRAALQTMVHAAQRLRAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009442
EMBL· GenBank· DDBJ
AAO29157.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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