Q875V6 · Q875V6_NAUCA

Function

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for active site, binding site.

152550100150200250300350400450500
TypeIDPosition(s)Description
Active site331Proton acceptor
Binding site339Zn2+ (UniProtKB | ChEBI)
Binding site342Zn2+ (UniProtKB | ChEBI)
Binding site363Zn2+ (UniProtKB | ChEBI)
Binding site366Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone H4K16 deacetylase activity
Molecular Functiontransferase activity

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • SIR2

Organism names

Accessions

  • Primary accession
    Q875V6

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Region1-52Disordered
Domain204-492Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    525
  • Mass (Da)
    59,883
  • Last updated
    2003-06-01 v1
  • Checksum
    7D278693B194DE10
MTTLSADATTDLLGNNKRPYSIDSIPGADSTMNSDLSLNKKPKLDDAKEDVEDDDQSLSVFARRAENKSKSENMIIPKIPSHPIILSKDPESGKYILPKINKEDSLNARMFLKYYGLKSFLDSFLPEELNSLYIYFLIKLLGFEIKDRDLLNVVYEFIDPDMHIDDNESLERIEYEDPLEKKQAVRLIKDLQKAINKVLCTRLRLSNFYTIEHFVDKLKTANRILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYDIFMQNPSVFYNISHMILPPDNIYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIKAENLVQCHGSFATASCITCHWKLPGEKIFENIRKMELPLCPYCYKKRREYFPNDNAKLDPTLAKNSGKFTGQALKSYGVLKPDITFFGEALPSKFHKTIREDILKCDLLICIGTSLKVAPVSEIVNMVPAHVPQVLINRDPVRHAEFDLNLLGFCDDVAALVAQKSGWDIPHKKWEILKTEVFDCIEKEKGTYNISQHEDTN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY144963
EMBL· GenBank· DDBJ
AAO32526.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp