Q875Q8 · MYO2_LACK1
- ProteinMyosin-2
- GeneMYO2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1554 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | myosin complex | |
Cellular Component | vesicle | |
Molecular Function | actin filament binding | |
Molecular Function | ATP binding | |
Molecular Function | microfilament motor activity | |
Biological Process | actin filament organization | |
Biological Process | protein transport | |
Biological Process | vesicle transport along actin filament |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMyosin-2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Lachancea
Accessions
- Primary accessionQ875Q8
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000123488 | 1-1554 | Myosin-2 | |||
Sequence: MSYEVGTRCWYPDKQQGWIGGEITKHTNLSNKHQLELTLEDNQIVEIESETLDETKDDRLPLLRNPPILEATEDLTSLSYLNEPAVLHAIKARYAQLNIYTYSGIVLIATNPFDRVEQLYSQDMIQAYAGKRRGELEPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEQNNEENAHHNLEMSETEKKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKEISIIGARIRTYLLERSRLVFQPKSERNYHIFYQLLAGLTNEEKSQLKLTGVEDYHYMNQGGEAQIKGIDDAEEYQTTVEALSLVGISKDTQYQLFKILAALLHIGNVEIKKTRNDASLSSDEPNLAIACELLGIDSFNFAKWITKKQINTRSEKIVSNLNYNQALVARDSVAKFIYSALFEWLVDNINTVLCNPEVASEINSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIENKLGILSLLDEESRLPAGSDETWTQKLYQTLDKPPTNTVFSKPRFGQTKFVVSHYALDVSYDVEGFIEKNRDTVSDGHLEVLKASTNETLLSILETLDKHAAKLAEKEQVNKKPGPARMVNRKPTLGSIFKQSLIELMGTINSTNVHYIRCIKPNEVKEAWVFDNLMVLSQLRACGVLETIRISCAGFPSRWTYNEFVLRYHILIPSEHWSKMFSSDTTEEDIRDLCRTILGAIVEDKQKYQLGNTKIFFKAGMLAYLEKLRSDRLHNSSVLIQKKVKAVYYRKKYLAIISSIRNFHSRSEGFLTRQRVDLEFKTQAAILIQSMVRSTSTRNKTISLLSAITRLQSLVRKQLAQKELLQRRQRDAAVSIQKKIRAFEPRQSFNTTRRSTVVVQSLVRKKFAQKKLKDLKTEAKSVNHLKEVSYKLENKVIQLTESLAEKVKENKGMTARIQELQQSLNESANIKELLNSQKDEHSKVLQQQKDAHDVQFNEVQEKLVNAKKEVEEAKEEIEQLIAKQDELKAEVRTKIEELNKAKKTFTEFQTQNSDLKNEVKSLKDEIARLQAAVRSGVTSSTITSTPTASRRFSAHSSVADGTSPRQLNVISMNNGGIEDDARSTASALSQINDELYKLLEDTKSLNTEIVEGLLKGFKIPETGVAVELTRKEVLYPARILIIVLSDMWRLGLTKQSESFLAEVLSTIQKLVTNLKGDDMILHGAFWLTNVRELYSFVVFAQESILNDDSYNNGLNEDEYKEYVTLVTELKDDFESLSYNIYNIWLKKLQKDLERKAISAVVMSQSLPGFIAPESSPFLPKLFSQSSHYKMDDILTFFNNIYWSMKTYHVETEVFREVIMTLLKYVDAICFNDLIMRRNFLSWKRGLQLNYNVTRLEEWCKSHQLPEGTECLQHMLQASKLLQLKKANLEDINIIWEICSSLKPAQIQKLISQYAVADYEVPIPQEILNFVADRVKKESSLSSDGKSQTHSSDIFLSVDSGPFEDPFGQIETREFGKIEAYIPAWLNLPITRRVVELVTQHVTVQESQRTE |
Interaction
Subunit
Homodimer. Interacts with calmodulin (CMD1) and the myosin light chain MLC1 through its IQ repeats (By similarity).
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-57 | Myosin N-terminal SH3-like | ||||
Sequence: EVGTRCWYPDKQQGWIGGEITKHTNLSNKHQLELTLEDNQIVEIESETLDETKD | ||||||
Domain | 70-774 | Myosin motor | ||||
Sequence: EATEDLTSLSYLNEPAVLHAIKARYAQLNIYTYSGIVLIATNPFDRVEQLYSQDMIQAYAGKRRGELEPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEQNNEENAHHNLEMSETEKKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKEISIIGARIRTYLLERSRLVFQPKSERNYHIFYQLLAGLTNEEKSQLKLTGVEDYHYMNQGGEAQIKGIDDAEEYQTTVEALSLVGISKDTQYQLFKILAALLHIGNVEIKKTRNDASLSSDEPNLAIACELLGIDSFNFAKWITKKQINTRSEKIVSNLNYNQALVARDSVAKFIYSALFEWLVDNINTVLCNPEVASEINSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIENKLGILSLLDEESRLPAGSDETWTQKLYQTLDKPPTNTVFSKPRFGQTKFVVSHYALDVSYDVEGFIEKNRDTVSDGHLEVLKASTNETLLSILETLDKHAAKLAEKEQVNKKPGPARMVNRKPTLGSIFKQSLIELMGTINSTNVHYIRCIKPNEVKEAWVFDNLMVLSQLRACGVLETIRISCAGFPSRWTYNEFVLRYHILIPSEHWSKMFSSDTTEEDIRDLCRTILGAIVEDKQKYQLGNTKIFFKAGMLAYLEKLRS | ||||||
Region | 443-523 | Actin-binding | ||||
Sequence: FIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIENKLGILSLLDEE | ||||||
Domain | 778-798 | IQ 1 | ||||
Sequence: HNSSVLIQKKVKAVYYRKKYL | ||||||
Domain | 800-824 | IQ 2 | ||||
Sequence: IISSIRNFHSRSEGFLTRQRVDLEF | ||||||
Domain | 825-847 | IQ 3 | ||||
Sequence: KTQAAILIQSMVRSTSTRNKTIS | ||||||
Domain | 848-872 | IQ 4 | ||||
Sequence: LLSAITRLQSLVRKQLAQKELLQRR | ||||||
Domain | 873-895 | IQ 5 | ||||
Sequence: QRDAAVSIQKKIRAFEPRQSFNT | ||||||
Domain | 896-925 | IQ 6 | ||||
Sequence: TRRSTVVVQSLVRKKFAQKKLKDLKTEAKS | ||||||
Coiled coil | 926-1079 | |||||
Sequence: VNHLKEVSYKLENKVIQLTESLAEKVKENKGMTARIQELQQSLNESANIKELLNSQKDEHSKVLQQQKDAHDVQFNEVQEKLVNAKKEVEEAKEEIEQLIAKQDELKAEVRTKIEELNKAKKTFTEFQTQNSDLKNEVKSLKDEIARLQAAVRS | ||||||
Region | 1080-1554 | Non alpha-helical, tail domain | ||||
Sequence: GVTSSTITSTPTASRRFSAHSSVADGTSPRQLNVISMNNGGIEDDARSTASALSQINDELYKLLEDTKSLNTEIVEGLLKGFKIPETGVAVELTRKEVLYPARILIIVLSDMWRLGLTKQSESFLAEVLSTIQKLVTNLKGDDMILHGAFWLTNVRELYSFVVFAQESILNDDSYNNGLNEDEYKEYVTLVTELKDDFESLSYNIYNIWLKKLQKDLERKAISAVVMSQSLPGFIAPESSPFLPKLFSQSSHYKMDDILTFFNNIYWSMKTYHVETEVFREVIMTLLKYVDAICFNDLIMRRNFLSWKRGLQLNYNVTRLEEWCKSHQLPEGTECLQHMLQASKLLQLKKANLEDINIIWEICSSLKPAQIQKLISQYAVADYEVPIPQEILNFVADRVKKESSLSSDGKSQTHSSDIFLSVDSGPFEDPFGQIETREFGKIEAYIPAWLNLPITRRVVELVTQHVTVQESQRTE | ||||||
Region | 1082-1109 | Disordered | ||||
Sequence: TSSTITSTPTASRRFSAHSSVADGTSPR | ||||||
Domain | 1205-1480 | Dilute | ||||
Sequence: AEVLSTIQKLVTNLKGDDMILHGAFWLTNVRELYSFVVFAQESILNDDSYNNGLNEDEYKEYVTLVTELKDDFESLSYNIYNIWLKKLQKDLERKAISAVVMSQSLPGFIAPESSPFLPKLFSQSSHYKMDDILTFFNNIYWSMKTYHVETEVFREVIMTLLKYVDAICFNDLIMRRNFLSWKRGLQLNYNVTRLEEWCKSHQLPEGTECLQHMLQASKLLQLKKANLEDINIIWEICSSLKPAQIQKLISQYAVADYEVPIPQEILNFVADRVKK |
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,554
- Mass (Da)178,198
- Last updated2003-06-01 v1
- Checksum412A25F7A4C3A8FD