Q874B9 · EF2_PICPA

Function

function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Catalytic activity

Features

Showing features for binding site.

1842100200300400500600700800
TypeIDPosition(s)Description
Binding site26-33GTP (UniProtKB | ChEBI)
Binding site158-161GTP (UniProtKB | ChEBI)
Binding site213-215GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentribonucleoprotein complex
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 2
  • EC number
  • Short names
    EF-2

Gene names

    • Name
      EFT1
    • Synonyms
      PEF1

Organism names

Accessions

  • Primary accession
    Q874B9

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000910201-842Elongation factor 2
Modified residue699Diphthamide

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-253tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    842
  • Mass (Da)
    93,469
  • Last updated
    2003-06-01 v1
  • Checksum
    BED5CF616E47F1A6
MVNFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMGDDDVKEIKQKTEGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVTKEDLYQSFARTVESVNVVIATYTDKTIGDNQVYPEQGTVAFGSGLHGWAFTVRQFATRYSKKFGVDRIKMMERLWGDSYFNPKTKKWTNKDKDAAGKPLERAFNMFVLDPIFRLFAAIMNFKKDEIPVLLEKLEINLKREEKELEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAETLYEGPSDDQFCIGIRECDPKAELMVYISKMVPTSDKGRFYAFGRVFSGTVKSGQKVRIQGPNYVPGKKEDLFIKAVQRTVLMMGRTVEPIDDVPAGNILGIVGIDQFLLKSGTLTTNEAAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYISESGEHIVAGTGELHLEICLQDLQDDHAGVPLKISPPVVTYRETVTNESSMTALSKSQNKHNRIYLKAQPIDEELSLAIEEGKVHPRDDFKARARIMADEYGWDVTDARKIWCFGPDGTGANLVVDQSKAVQYLHEIKDSVVAGFQLATKEGPILGENMRSVRVNILDVTLHADAIHRGGGQVIPTMKRVTYAAFLLAEPAIQEPIFLVEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTVKAYLPVNESFGFTGELRQATAGQAFPQMVFDHWANMNGNPLDPASKVGEIVLAARKRQGMKENVPGYEEYYDKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY219033
EMBL· GenBank· DDBJ
AAO39212.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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