Q872I5 · INO80_NEUCR

Function

function

ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1143-1150ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentIno80 complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent chromatin remodeler activity
Molecular FunctionDNA binding
Molecular Functionhistone binding
Biological Processchromatin remodeling
Biological ProcessDNA repair
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chromatin-remodeling ATPase INO80
  • EC number
  • Alternative names
    • Chromatin remodeling factor 2-1

Gene names

    • Name
      crf2-1
    • Synonyms
      ino80
    • ORF names
      B24G20.040, NCU08919

Organism names

Accessions

  • Primary accession
    Q872I5
  • Secondary accessions
    • Q7S251
    • V5ILU4

Proteomes

    • Identifier
    • Component
      Chromosome 2, Linkage Group V

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000743271-1997Chromatin-remodeling ATPase INO80

Proteomic databases

Interaction

Subunit

Component of the INO80 chromatin-remodeling complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain, motif.

TypeIDPosition(s)Description
Region1-378Disordered
Compositional bias9-23Basic and acidic residues
Compositional bias30-44Pro residues
Compositional bias81-109Polar residues
Compositional bias127-153Polar residues
Compositional bias155-170Pro residues
Compositional bias171-187Polar residues
Compositional bias192-207Pro residues
Compositional bias229-250Polar residues
Compositional bias275-296Polar residues
Compositional bias297-320Basic and acidic residues
Compositional bias321-378Polar residues
Region397-579Disordered
Compositional bias402-486Polar residues
Compositional bias491-544Basic and acidic residues
Coiled coil666-735
Compositional bias674-691Basic and acidic residues
Region674-858Disordered
Compositional bias707-725Basic and acidic residues
Compositional bias767-791Basic and acidic residues
Compositional bias807-858Basic and acidic residues
Domain881-1006DBINO
Domain1130-1302Helicase ATP-binding
Motif1253-1256DEAQ box
Domain1702-1858Helicase C-terminal
Region1891-1986Disordered
Compositional bias1912-1934Basic and acidic residues

Domain

The DBINO region is involved in binding to DNA.

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,997
  • Mass (Da)
    223,073
  • Last updated
    2007-12-04 v3
  • Checksum
    749AF1E8F98F1142
MDHFSTVLQRPPHFDEDGTEGRGDRGNGAGPGPAPPPPPPRGGLRDILNPVSSNSAVQSQAAAAAPPPPPAVASSSLHGIAASVPPPSSTNSMRATPHSSSSFNLRSPTREPSEYRHPLSSLATPAPFAASPPTSIANANNTNNNNALGAAGSLSSQPPPPPPTGPRSILNPPTPSQQHQQQHHHPNPFVAASAPSLPPPPSSLQAPPAITPIAGLSAPAPASGSLPLSAGGIGNSITVSSSSQPPARASQLHAPSAYYSPAESFRDRDSSVREKSSTGGSFYDPTAEASNGISGSSPRKDRDRDRDHRGTTRESQRRSVSGHSDTGSSWRNATQTSASNKTRDPYNYSPSSADYYNTRKKENYPVDNTTSSSIAAPSNFTVATRSPVAALSHPASIAAPASVGSLTGSISPRLSLRPPSMASPTIRSAVLANPTNGTTSTALPALGRNDSPPSKMSPGTSTNPSRAAGVMSFSNILSSSEPVPRPRATSPNNPDDDDDVPMKVERADSSEKVVKEKKERKPRQPKQPRISDIRHSESTPKGRRGSTKQESPLPNIRIPAKRMANGAPKQQKTFSAENEEKIRKAMDRIETRELPHEDEFEEELRLWRERREYKRQQMNQRDLRQRRQRRADYTEVEAQKLKLHADFGKRRYDDLNYDDALQEVRERELFAEKERKKDMQRKRRREKSMATTMEAKAAALARASAAQDEAERQKYMREAERANKKVQQTRLILQKGIKGPSRNTGPIEPNLEGGTMATFQAENMEPGKTKGKGRAGARPKKSKEQKQAEKDAAEAAQAALDAGLELPPKEETNKIRIKLTKTKAPKEADVDKDKENKEPQEPKEPKEPKEKVIKEKVVEEPKDPLELKFQSKGFNQIYDQIWRDLARKDVNKVFRLAIDSYSTKSSNLKKTAILASKEAKRWQLRTNKGTKDLQARAKRVMRDMMGFWKRNEREERDLRKAAEKQELENARKEEADREAARQKRKLNFLISQTELYSHFIGKKIKTNEVERSTDHPDEIAAEKDKIPENEMDIEVPTGPIGAKVTNFENLDFDAEDESTLRAAAMANAQNAIAEAQKKAREFNKEESKLDEDGEMNFQNPTMMGDVEIEQPKLLNCQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAEKYDIWGPFLVVAPASTLHNWQQEITKFVPQFKVLPYWGTAGDRKVLRKFWDRKHTTYKKDAPFHVMITSYQLVVSDVAYFQKMKWQYMILDEAQAIKSSQSSRWKCLLGFHCRNRLLLTGTPIQNNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKHVQKELGDKIEMDVFCDLTYRQRAMYANLRNQISIMDLIEKATLGDDDSASLMNLVMQFRKVCNHPDLFERADTASPYSFGHFAETASFIREGSQVTVGYSTRSLIQYELPRLLWRDGGRLHKAGEDNQVAGWRNQWLNEKFNIWTPEHIRESLAGTDNFSWLRFADTSYEEAYRASHKDLFARAVEMSTKKNRLAEIKIAYDEPEDLNFTPAHALFHIREREDRRPLAEITEQGILGSLMNVSRSAFSETGLGRLEQAAAPKASAPPIEVVCDSRSAVVERENIMFNAPMRKVLFGPTLAEEKALVVQKVPPSRYPPPALLPAPDKEKQKFTNITVPSMRRFVTDSGKLAKLDELLRELKENGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQTRPEIFIFLLSTRAGGLGINLTSADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRLITRGTIEERIRKRAMQKEEVQRVVITGGSSAAGGGVDFSGRRAPENRNRDIAMWLADDEQAEMIEKRERELLESGELDKMQKKSRGGNKRKRGGAGGEGKEVSLDEMYHEGEGNFDDGGNNIKGSGTATPNGAAGGEGGDGKGAVGGAAKKRKTGGSKKAKTTKQRLAIADGEIDI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
V5IMG6V5IMG6_NEUCRcrf2-12011

Sequence caution

The sequence CAD70746.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias9-23Basic and acidic residues
Compositional bias30-44Pro residues
Compositional bias81-109Polar residues
Compositional bias127-153Polar residues
Compositional bias155-170Pro residues
Compositional bias171-187Polar residues
Compositional bias192-207Pro residues
Compositional bias229-250Polar residues
Compositional bias275-296Polar residues
Compositional bias297-320Basic and acidic residues
Compositional bias321-378Polar residues
Compositional bias402-486Polar residues
Compositional bias491-544Basic and acidic residues
Compositional bias674-691Basic and acidic residues
Compositional bias707-725Basic and acidic residues
Compositional bias767-791Basic and acidic residues
Compositional bias807-858Basic and acidic residues
Compositional bias1912-1934Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX294010
EMBL· GenBank· DDBJ
CAD70746.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CM002240
EMBL· GenBank· DDBJ
ESA42365.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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