Data suggest that the nuclear receptor co-repressor 1/2 protein NCoR-1/NCoR-2 paralogs have been subject to a mix of shared and distinct selective pressures resulting in the pattern of divergent and convergent alternative-splicing observed in extant species.
vitamin E and PIAS1-shRNA partially decreased ROS production and IKK activation induced by high glucose and PA exposure. These data indicate that ROS-IKK-PIAS1 pathway mediates PPARgamma sumoylation leading to endothelium insulin resistance (IR) via stabilizing PPARgamma-NcoR complex.
Microarray analysis revealed differential expression of three vitamin D associated genes in the aortic adventitia in rheumatoid arthritis (RA) and non-RA patients with coronary artery disease: while the expression of GADD45A and NCOR1 was higher the expression of PON2 was lower in RA patients.
Survival of developing thymocytes is regulated by NCOR1. NCOR1 controls positive and negative selection of thymocytes during T cell development. HDAC3 interacts with NCOR1 corepressor complexes. Review.
19 patients with neurodevelopmental disorders harboring a rare deletion inherited from a healthy parent were investigated by whole-exome sequencing to search for SNV on the contralateral segment. This strategy allowed us to identify a candidate variant in two patients in the NUP214 and NCOR1 genes.
Authors previously shown that Nuclear Receptor Corepressor 1 (NCoR) and the thyroid hormone receptor beta1 (TRbeta) inhibit tumor invasion. Here they show that these molecules repress VEGF-C and VEGF-D gene transcription in breast cancer cells reducing lymphatic vessel density and sentinel lymph node invasion in tumor xenografts.
Nuclear Receptor Corepressor 1 is an important transcriptional regulator that interacts with nuclear receptors and other transcription factors. Recent results have shown the presence of inactivating mutations or deletions of the nuclear receptor corepressor 1 gene in human tumors.
NCOR1 function declines with prostate cancer progression. Reduction in NCOR1 levels causes bicalutamide resistance in LNCaP cells and compromises response to bicalutamide in mouse prostate in vivo
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