Q86Y79 · PTH_HUMAN
- ProteinPeptidyl-tRNA hydrolase
- GenePTRH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids214 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (PubMed:30244831).
Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831).
Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831).
Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831).
Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831).
Catalytic activity
- an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aminoacyl-tRNA hydrolase activity | |
Molecular Function | RNA binding | |
Biological Process | rescue of stalled ribosome |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptidyl-tRNA hydrolase
- EC number
- Short namesPTH
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86Y79
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 46 | Abolished peptidyl-tRNA activity. | ||||
Sequence: H → N | ||||||
Mutagenesis | 121 | Abolished peptidyl-tRNA activity. | ||||
Sequence: D → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 301 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000240441 | 1-214 | Peptidyl-tRNA hydrolase | |||
Sequence: MRPGGFLGAGQRLSRAMSRCVLEPRPPGKRWMVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWTRDRHCAADLALAPLGDAQLVLLRPRRLMNANGRSVARAAELFGLTAEEVYLVHDELDKPLGRLALKLGGSARGHNGVRSCISCLNSNAMPRLRVGIGRPAHPEAVQAHVLGCFSPAEQELLPLLLDRATDLILDHIRERSQGPSLGP |
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q86Y79 | ANKRD28 O15084 | 3 | EBI-2602515, EBI-359567 | |
BINARY | Q86Y79 | FAM9B Q8IZU0 | 3 | EBI-2602515, EBI-10175124 | |
BINARY | Q86Y79 | LCN2 P80188 | 3 | EBI-2602515, EBI-11911016 | |
BINARY | Q86Y79 | PICK1 Q9NRD5 | 3 | EBI-2602515, EBI-79165 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length214
- Mass (Da)22,937
- Last updated2003-06-01 v1
- ChecksumDBA3959411DA8248
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
C9J7Z1 | C9J7Z1_HUMAN | PTRH1 | 182 | ||
A0A096LPA3 | A0A096LPA3_HUMAN | PTRH1 | 162 | ||
A0A096LP22 | A0A096LP22_HUMAN | PTRH1 | 172 | ||
A0A096LP34 | A0A096LP34_HUMAN | PTRH1 | 137 | ||
A0A286YF52 | A0A286YF52_HUMAN | PTRH1 | 159 | ||
A0A286YER0 | A0A286YER0_HUMAN | PTRH1 | 35 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC047012 EMBL· GenBank· DDBJ | AAH47012.1 EMBL· GenBank· DDBJ | mRNA |