Q86XD5 · F131B_HUMAN

  • Protein
    Protein FAM131B
  • Gene
    FAM131B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein FAM131B

Gene names

    • Name
      FAM131B
    • Synonyms
      KIAA0773

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q86XD5
  • Secondary accessions
    • A4D2H6
    • A6NDW3
    • A8K605
    • B8ZZN2
    • D3DXE3

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_053920307in dbSNP:rs17854363

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 457 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, chain, lipidation, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtIn isoform Q86XD5-2; Removed
ChainPRO_00002530321-332UniProtProtein FAM131B
Lipidation2UniProtIn isoform Q86XD5-2; N-myristoyl glycine
Modified residue47UniProtPhosphoserine
Modified residue (large scale data)47PRIDEPhosphoserine
Modified residue (large scale data)59PRIDEPhosphoserine
Modified residue (large scale data)105PRIDEPhosphoserine
Modified residue114UniProtPhosphoserine
Modified residue (large scale data)114PRIDEPhosphoserine
Modified residue117UniProtPhosphoserine
Modified residue (large scale data)117PRIDEPhosphoserine
Modified residue295UniProtPhosphoserine
Modified residue297UniProtPhosphoserine
Modified residue (large scale data)297PRIDEPhosphoserine
Modified residue313UniProtPhosphoserine
Modified residue (large scale data)313PRIDEPhosphoserine
Modified residue316UniProtPhosphothreonine
Modified residue317UniProtPhosphoserine
Modified residue318UniProtPhosphoserine
Modified residue322UniProtPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q86XD5TINF2 Q9BSI42EBI-11308812, EBI-717399

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-22Disordered
Region95-114Disordered
Region222-332Disordered
Compositional bias270-307Basic and acidic residues
Compositional bias309-332Polar residues

Sequence similarities

Belongs to the FAM131 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q86XD5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    332
  • Mass (Da)
    35,769
  • Last updated
    2006-10-17 v3
  • Checksum
    35FE42189855034F
MDSTSSLHGSSLHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKTPAVQPQHSHESVRRDTDAYSDLSDGEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNYQELMDSQDALAQAPMDGWPHSYVSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFDDSQPSLHEMGPSQPASGYSALEPPPLLGGDTDWAPGVGAVDLARGPAEEEKRPLAPEEEEDAGCRDLESLSPREDPEMSTALSRKVSDVTSSGVQSFDEEEGEANN

Q86XD5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-30: MDSTSSLHGSSLHRPSTEQTRTDFSWDGIN → MGCIGSRTVGNEVIAVDWKGLKDVDQINMDSTSSLHGSSLHRPSTE

Q86XD5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MGCIGSRTVGNEVIAVDWKGLKDVDQINM

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0Y3V6H0Y3V6_HUMANFAM131B11
E5RJ60E5RJ60_HUMANFAM131B63
E5RI17E5RI17_HUMANFAM131B44

Sequence caution

The sequence AAS07501.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0467981in isoform 3
Alternative sequenceVSP_0416331-30in isoform 2
Sequence conflict47in Ref. 2; CAD89938
Sequence conflict141in Ref. 2; CAD89938
Compositional bias270-307Basic and acidic residues
Sequence conflict285in Ref. 6; AAH45611
Sequence conflict291in Ref. 6; AAH45611
Compositional bias309-332Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK291470
EMBL· GenBank· DDBJ
BAF84159.1
EMBL· GenBank· DDBJ
mRNA
AL832579
EMBL· GenBank· DDBJ
CAD89938.1
EMBL· GenBank· DDBJ
mRNA
AC093673
EMBL· GenBank· DDBJ
AAS07501.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CH236959
EMBL· GenBank· DDBJ
EAL23787.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471198
EMBL· GenBank· DDBJ
EAW51853.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471198
EMBL· GenBank· DDBJ
EAW51854.1
EMBL· GenBank· DDBJ
Genomic DNA
BC045611
EMBL· GenBank· DDBJ
AAH45611.2
EMBL· GenBank· DDBJ
mRNA
BC050543
EMBL· GenBank· DDBJ
AAH50543.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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