Q86X53 · ERIC1_HUMAN
- ProteinGlutamate-rich protein 1
- GeneERICH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutamate-rich protein 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86X53
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_035915 | 365 | in a colorectal cancer sample; somatic mutation; dbSNP:rs774405503 | |||
Sequence: L → F | ||||||
Natural variant | VAR_050974 | 403 | in dbSNP:rs1703879 | |||
Sequence: R → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 809 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000087029 | 1-443 | UniProt | Glutamate-rich protein 1 | |||
Sequence: MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPDHARVISAFFSYWITHILPEKSSD | |||||||
Modified residue | 12 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 56 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 62 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 238 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 238 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 254 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 254 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 277 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 339 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q86X53 | MTG1 Q9BT17 | 3 | EBI-12902263, EBI-2602570 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 15-333 | Disordered | ||||
Sequence: QRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTIT | ||||||
Compositional bias | 29-43 | Polar residues | ||||
Sequence: EPQTLAVQNPPKKVT | ||||||
Compositional bias | 53-67 | Polar residues | ||||
Sequence: EPLTDTGSETPTARR | ||||||
Compositional bias | 110-124 | Basic residues | ||||
Sequence: KRRRIRKHKSKKKFK | ||||||
Compositional bias | 132-154 | Polar residues | ||||
Sequence: EQAELEKQQSLLQEKSQRQHTDG | ||||||
Compositional bias | 160-175 | Basic residues | ||||
Sequence: NKKRKLKKKQQIKRKK | ||||||
Compositional bias | 200-222 | Acidic residues | ||||
Sequence: EGVGEACEEDGVDTSEEDPTLAG | ||||||
Compositional bias | 223-253 | Basic and acidic residues | ||||
Sequence: EEDVKDTREEDGADASEEDLTRARQEEGADA | ||||||
Compositional bias | 263-297 | Basic and acidic residues | ||||
Sequence: EEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREED | ||||||
Compositional bias | 298-328 | Acidic residues | ||||
Sequence: GADASEEDPTWAGEEEGADSGEEDGADASEE |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)48,984
- Last updated2003-06-01 v1
- ChecksumB343667314588823
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0YBT6 | H0YBT6_HUMAN | ERICH1 | 124 | ||
H0YB25 | H0YB25_HUMAN | ERICH1 | 223 | ||
A0A1Y8EN93 | A0A1Y8EN93_HUMAN | ERICH1 | 7 | ||
E5RHA3 | E5RHA3_HUMAN | ERICH1 | 345 |
Sequence caution
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 3 | in Ref. 4; AAF28997 | ||||
Sequence: A → Q | ||||||
Compositional bias | 29-43 | Polar residues | ||||
Sequence: EPQTLAVQNPPKKVT | ||||||
Compositional bias | 53-67 | Polar residues | ||||
Sequence: EPLTDTGSETPTARR | ||||||
Compositional bias | 110-124 | Basic residues | ||||
Sequence: KRRRIRKHKSKKKFK | ||||||
Compositional bias | 132-154 | Polar residues | ||||
Sequence: EQAELEKQQSLLQEKSQRQHTDG | ||||||
Compositional bias | 160-175 | Basic residues | ||||
Sequence: NKKRKLKKKQQIKRKK | ||||||
Compositional bias | 200-222 | Acidic residues | ||||
Sequence: EGVGEACEEDGVDTSEEDPTLAG | ||||||
Compositional bias | 223-253 | Basic and acidic residues | ||||
Sequence: EEDVKDTREEDGADASEEDLTRARQEEGADA | ||||||
Compositional bias | 263-297 | Basic and acidic residues | ||||
Sequence: EEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREED | ||||||
Compositional bias | 298-328 | Acidic residues | ||||
Sequence: GADASEEDPTWAGEEEGADSGEEDGADASEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK290264 EMBL· GenBank· DDBJ | BAF82953.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471181 EMBL· GenBank· DDBJ | EAW51467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC046243 EMBL· GenBank· DDBJ | AAH46243.1 EMBL· GenBank· DDBJ | mRNA | ||
AF161437 EMBL· GenBank· DDBJ | AAF28997.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |