Q86WS4 · RDIC1_HUMAN
- ProteinRegulator of DNA class I crossover intermediates 1
- GeneREDIC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids652 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation. Required for normal germline development and fertility. Required for meiotic progression, complete chromosomal synapsis and crossover formation. Binds double-stranded DNA. However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure. Probably not required for formation of DNA double-strand breaks (DSBs). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs.
Miscellaneous
Incomplete or abnormal chromosome synapsis and significantly fewer MLH1 foci observed in spermatocytes from a case of non-obstructive azoospermia.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 1-231 | Binds DNA containing a D-loop | ||||
Sequence: MNWVGGSRSRVLIKQERRKQKEYFEKHRLKSKMKSLGVLSPVKNSAVSLDILNLYMVNQISCKKKIPETVRKPTHVNMNRDIKMPLRKHNLELTMSPHCVPSKLCLDDTETNVNCQRLSSKEDLGPVQSQGMDSYSMLHPQFSKIENCSFTPSSFSVELPSNRHISKLNFTSGIAPTPQKLAYEKKQNDQRSTVNCSDSLLSKLNKSQDVFSPSHKTTRFGTLFERLNSLG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | DNA binding | |
Molecular Function | RNA binding | |
Biological Process | meiotic cell cycle |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRegulator of DNA class I crossover intermediates 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86WS4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: In pachytene spermatocytes, localized along autosomal axes and the synapsed pseudoautosomal region on sex chromosomes, decreasing rapidly after early pachytene, by mid- or late pachytene, and disappearing in the diplotene stage. Also detected on the paired regions of homologous chromosomes in zygotene and pachytene oocytes, colocalizing with MSH4. Chromosomal localization of REDIC1 is mainly dependent on meiotic DNA double-strand breaks (DSBs) and interhomolog strand invasion. In spermatocytes from early zygotene to early pachytene, more than 90% of REDIC1 foci colocalize with RPA2. Probably localizes first to recombination intermediates and later colocalizes with MLH1 at crossover sites.
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_061610 | 13 | in dbSNP:rs58302581 | |||
Sequence: I → L |
Variants
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The viewer provides 888 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000348051 | 1-652 | Regulator of DNA class I crossover intermediates 1 | |||
Sequence: MNWVGGSRSRVLIKQERRKQKEYFEKHRLKSKMKSLGVLSPVKNSAVSLDILNLYMVNQISCKKKIPETVRKPTHVNMNRDIKMPLRKHNLELTMSPHCVPSKLCLDDTETNVNCQRLSSKEDLGPVQSQGMDSYSMLHPQFSKIENCSFTPSSFSVELPSNRHISKLNFTSGIAPTPQKLAYEKKQNDQRSTVNCSDSLLSKLNKSQDVFSPSHKTTRFGTLFERLNSLGNRNLLTKSPAVIMDEDCRSTDEIRQSDYITEKHSIQHIWGKNGKEVSNFLEDVNQSTPNLLSENCDSFVSQNMINVLNIDEQRIKKTFNKCDYDSMGDTCVVTSSDKNHVTDRCIRNIFTVPELTFSNSTLNKTSYPEKCQPNKKYQREYNKNERNDLSTSFENDYYPSSSERKEKFENDYQEKTPQKSIQKYPANSMGNIPSEELHSKQSWDFGLDEILMEEGGIYSLKSKRISTKKISLDSAQSSRSTSYSPRPTDSCFSSSSDLPSEDEDQISQQIEDSNRMTIKTKEKMNNFYVERMAKLSGDRIVKNDDKIHKQNENFYQFSVKNNTDQFPQLQCNSAHILQNKTNDNCVLQAARCDAGIQTESESVMEEKLDVAIQCDLISKCTCRSDVSLCNLERCSGNIKADTTGGQEIHKNN |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with MSH5. Interacts with TEX11.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q86WS4 | DYNLL1 P63167 | 3 | EBI-10286004, EBI-349105 | |
BINARY | Q86WS4 | DYNLL2 Q96FJ2 | 4 | EBI-10286004, EBI-742371 | |
BINARY | Q86WS4 | LMO4 P61968 | 3 | EBI-10286004, EBI-2798728 | |
BINARY | Q86WS4 | NXF1 Q9UBU9 | 3 | EBI-10286004, EBI-398874 | |
BINARY | Q86WS4 | TNPO2 O14787-2 | 3 | EBI-10286004, EBI-12076664 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 363-434 | Disordered | ||||
Sequence: NKTSYPEKCQPNKKYQREYNKNERNDLSTSFENDYYPSSSERKEKFENDYQEKTPQKSIQKYPANSMGNIPS | ||||||
Compositional bias | 373-390 | Basic and acidic residues | ||||
Sequence: PNKKYQREYNKNERNDLS | ||||||
Compositional bias | 399-416 | Basic and acidic residues | ||||
Sequence: PSSSERKEKFENDYQEKT | ||||||
Compositional bias | 417-434 | Polar residues | ||||
Sequence: PQKSIQKYPANSMGNIPS | ||||||
Compositional bias | 469-503 | Polar residues | ||||
Sequence: KISLDSAQSSRSTSYSPRPTDSCFSSSSDLPSEDE | ||||||
Region | 469-506 | Disordered | ||||
Sequence: KISLDSAQSSRSTSYSPRPTDSCFSSSSDLPSEDEDQI |
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q86WS4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length652
- Mass (Da)74,505
- Last updated2006-09-19 v3
- ChecksumDBE494C3C183E77C
Q86WS4-2
- Name2
Q86WS4-3
- Name3
- SynonymsHEL-206
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_035082 | 1-77 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 373-390 | Basic and acidic residues | ||||
Sequence: PNKKYQREYNKNERNDLS | ||||||
Compositional bias | 399-416 | Basic and acidic residues | ||||
Sequence: PSSSERKEKFENDYQEKT | ||||||
Compositional bias | 417-434 | Polar residues | ||||
Sequence: PQKSIQKYPANSMGNIPS | ||||||
Alternative sequence | VSP_035083 | 429-471 | in isoform 3 | |||
Sequence: MGNIPSEELHSKQSWDFGLDEILMEEGGIYSLKSKRISTKKIS → IWCTKCSEFKVIFTLIHYVLMLNLFLKSLRTAFQAFLNNDLQL | ||||||
Compositional bias | 469-503 | Polar residues | ||||
Sequence: KISLDSAQSSRSTSYSPRPTDSCFSSSSDLPSEDE | ||||||
Alternative sequence | VSP_035084 | 471-477 | in isoform 2 | |||
Sequence: SLDSAQS → CQYNCIS | ||||||
Alternative sequence | VSP_035086 | 472-652 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_035085 | 478-652 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK097445 EMBL· GenBank· DDBJ | BAC05057.1 EMBL· GenBank· DDBJ | mRNA | ||
EU668334 EMBL· GenBank· DDBJ | ACF94487.1 EMBL· GenBank· DDBJ | mRNA | ||
AC125491 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC038754 EMBL· GenBank· DDBJ | AAH38754.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC048120 EMBL· GenBank· DDBJ | AAH48120.3 EMBL· GenBank· DDBJ | mRNA |