Q86WH2 · RASF3_HUMAN
- ProteinRas association domain-containing protein 3
- GeneRASSF3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids238 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | microtubule | |
Cellular Component | plasma membrane | |
Molecular Function | identical protein binding | |
Biological Process | signal transduction |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRas association domain-containing protein 3
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86WH2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localized to microtubules in vascular endothelial cells.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_026724 | 232 | in dbSNP:rs74098110 | |||
Sequence: R → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 237 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylserine | ||||
Sequence: S | |||||||
Chain | PRO_0000240396 | 2-238 | UniProt | Ras association domain-containing protein 3 | |||
Sequence: SSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKLEEALREVWKPD | |||||||
Modified residue (large scale data) | 5 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 6 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 7 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 137 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q86WH2 | CBX8 Q9HC52 | 3 | EBI-2845202, EBI-712912 | |
BINARY | Q86WH2 | DAXX Q9UER7 | 3 | EBI-2845202, EBI-77321 | |
BINARY | Q86WH2 | FAM110A Q9BQ89 | 3 | EBI-2845202, EBI-1752811 | |
BINARY | Q86WH2 | ITPRIP Q8IWB1 | 3 | EBI-2845202, EBI-2556412 | |
BINARY | Q86WH2 | KDM1A O60341 | 3 | EBI-2845202, EBI-710124 | |
BINARY | Q86WH2 | KYNU Q16719-2 | 3 | EBI-2845202, EBI-12351611 | |
BINARY | Q86WH2 | LITAF Q99732 | 5 | EBI-2845202, EBI-725647 | |
BINARY | Q86WH2 | PARD6B Q9BYG5 | 3 | EBI-2845202, EBI-295391 | |
BINARY | Q86WH2 | RASSF3 Q86WH2 | 2 | EBI-2845202, EBI-2845202 | |
BINARY | Q86WH2 | RPRD1B Q9NQG5 | 3 | EBI-2845202, EBI-747925 | |
BINARY | Q86WH2 | STK3 Q13188 | 7 | EBI-2845202, EBI-992580 | |
BINARY | Q86WH2 | STK4 Q13043 | 7 | EBI-2845202, EBI-367376 | |
BINARY | Q86WH2 | TENT5D Q8NEK8 | 3 | EBI-2845202, EBI-744726 | |
BINARY | Q86WH2 | TFRC P02786 | 3 | EBI-2845202, EBI-355727 | |
BINARY | Q86WH2 | TRIM59 Q8IWR1 | 3 | EBI-2845202, EBI-10262539 | |
BINARY | Q86WH2 | ZNF410 Q86VK4-3 | 3 | EBI-2845202, EBI-11741890 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 26-48 | Disordered | ||||
Sequence: RAPQGKPRSGQQDVEKEKETHSY | ||||||
Domain | 79-186 | Ras-associating | ||||
Sequence: YTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHE | ||||||
Domain | 187-234 | SARAH | ||||
Sequence: IGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKLEEALREV |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q86WH2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsA
- Length238
- Mass (Da)27,562
- Last updated2003-06-01 v1
- Checksum2C8AD10649259811
Q86WH2-2
- Name2
- SynonymsB
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1B0GUG6 | A0A1B0GUG6_HUMAN | RASSF3 | 299 | ||
A0A1B0GWJ9 | A0A1B0GWJ9_HUMAN | RASSF3 | 64 |
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY217662 EMBL· GenBank· DDBJ | AAO61687.1 EMBL· GenBank· DDBJ | mRNA | ||
AY217663 EMBL· GenBank· DDBJ | AAO61688.1 EMBL· GenBank· DDBJ | mRNA | ||
BC100951 EMBL· GenBank· DDBJ | AAI00952.1 EMBL· GenBank· DDBJ | mRNA | ||
BC100949 EMBL· GenBank· DDBJ | AAI00950.1 EMBL· GenBank· DDBJ | mRNA |