Q86W33 · TPRA1_HUMAN

  • Protein
    Transmembrane protein adipocyte-associated 1
  • Gene
    TPRA1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity
Biological Processembryonic cleavage
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processlipid metabolic process
Biological Processnegative regulation of mitotic cell cycle phase transition

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane protein adipocyte-associated 1
  • Alternative names
    • Integral membrane protein GPR175
    • Transmembrane protein 227

Gene names

    • Name
      TPRA1
    • Synonyms
      GPR175, TMEM227
    • ORF names
      PP6566

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q86W33
  • Secondary accessions
    • A8MVB8
    • D3DNA9
    • Q8WZ24
    • Q96AJ6
    • Q9P2R4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane48-68Helical; Name=1
Transmembrane76-96Helical; Name=2
Transmembrane123-143Helical; Name=3
Transmembrane151-171Helical; Name=4
Transmembrane192-212Helical; Name=5
Transmembrane234-254Helical; Name=6
Transmembrane265-285Helical; Name=7

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00000760991-373Transmembrane protein adipocyte-associated 1
Glycosylation11N-linked (GlcNAc...) asparagine
Glycosylation23N-linked (GlcNAc...) asparagine
Glycosylation361N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous, with higher levels in heart, placenta and kidney.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1
Entry 2Number of experimentsIntAct
BINARY Q86W33NLGN3 Q9NZ94-23EBI-16424742, EBI-16423037
BINARY Q86W33-2GPR25 O001553EBI-18976295, EBI-10178951

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the UPF0359 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q86W33-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    373
  • Mass (Da)
    41,053
  • Last updated
    2003-06-01 v1
  • MD5 Checksum
    DB6C8415A8F04EC86D557B0F25F285F3
MDTLEEVTWANGSTALPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFLIFLLWKLPSARAKIRITSSPIFITFYILVFVVALVGIARAVVSMTVSTSNAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERISLPSRRSFYVYAGILALLNLLQGLGSVLLCFDIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDETEEPDVHLPQPYAVARREGLEAAGAAGASAASYSSTQFDSAGGVAYLDDIASMPCHTGSINSTDSERWKAINA

Q86W33-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 204-239: VYSLVVILPKTPLKERISLPSRRSFYVYAGILALLN → LGGASTCMRASWHCSTYCRGWGVCCCASTSSRGSAV
    • 240-373: Missing

Q86W33-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 204-293: VYSLVVILPKTPLKERISLPSRRSFYVYAGILALLNLLQGLGSVLLCFDIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFS → LCRCHNLPVLQLLRSAHLRGFPPGLLRLGAQDPLLLQMPSGRDRGARCTPTPALRCGPAGGPGGCRGCWGLSCQLLEHAVRLCRRGGLPG
    • 294-373: Missing

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WC44F8WC44_HUMANTPRA1225
C9JZ00C9JZ00_HUMANTPRA1166
C9JU06C9JU06_HUMANTPRA1203
C9JVW5C9JVW5_HUMANTPRA141

Features

Showing features for sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Sequence conflict141-142in Ref. 1; BAA89782
Alternative sequenceVSP_016932204-239in isoform 2
Alternative sequenceVSP_016934204-293in isoform 3
Alternative sequenceVSP_016933240-373in isoform 2
Alternative sequenceVSP_016935294-373in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB037108
EMBL· GenBank· DDBJ
BAA89782.1
EMBL· GenBank· DDBJ
mRNA
AF289568
EMBL· GenBank· DDBJ
AAL55752.1
EMBL· GenBank· DDBJ
mRNA
AC023593
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC084035
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471052
EMBL· GenBank· DDBJ
EAW79343.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471052
EMBL· GenBank· DDBJ
EAW79344.1
EMBL· GenBank· DDBJ
Genomic DNA
BC017058
EMBL· GenBank· DDBJ
AAH17058.1
EMBL· GenBank· DDBJ
mRNA
BC050711
EMBL· GenBank· DDBJ
AAH50711.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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