Q86VI1 · EX3L1_HUMAN

  • Protein
    Exocyst complex component 3-like protein
  • Gene
    EXOC3L1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexocyst
Cellular Componentsecretory granule
Cellular Componenttransport vesicle
Molecular FunctionSNARE binding
Biological Processexocyst localization
Biological Processexocytosis
Biological Processpeptide hormone secretion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Exocyst complex component 3-like protein
  • Alternative names
    • Protein Jiangli

Gene names

    • Name
      EXOC3L1
    • Synonyms
      EXOC3L

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q86VI1
  • Secondary accessions
    • A8K7I9
    • Q8NAD2
    • Q8TEN2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03700275in a breast cancer sample; somatic mutation; dbSNP:rs117403380
Natural variantVAR_037003514in a breast cancer sample; somatic mutation; dbSNP:rs142958191
Natural variantVAR_036959561in dbSNP:rs9939768
Natural variantVAR_036960634in dbSNP:rs16957212

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 905 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003094741-746Exocyst complex component 3-like protein

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-23Disordered
Region1-370Mediates interaction with EXOC2, EXOC4 and EXOC5

Sequence similarities

Belongs to the SEC6 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    746
  • Mass (Da)
    81,678
  • Last updated
    2009-02-10 v2
  • Checksum
    C762DE3E63D782C9
MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRSREVQRTCSLESRLKSVMQSYLEGVQTGVWQLAQAIEVVQGTREALSQARGLLQGMSQALQTLEPLRERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFLEAYVSLRELEQLREDTWAPLGGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPALLVAAVRVAEVETGRTTPLGQVPRDWRQRCLRALQEGLEQAHFGSPLLPAPGALPGWLEALRVALPVELATAEALVAPCCPPQYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADAFALLHWALHVYLGQEMMGSLELGPEADVSQLEPLLTLENIEQLEATFVANIQASVSQWLQNALDGEVAEWGREHGPNTDPSGSYYSPMPAIVLQILEENIRVASLVSESLQQRVHGMALSELGTFLRSFSDALIRFSRDHFRGKSMAPHYVPYLLAALNHKSALSSSVSVLQLDGAPSGALAPVEAALDELQRRIYRLVLEALQAELQPLFADLPSRQWLSSPELLQSVCERTGRFCRDFWRVRNPTVQLLLAEAERAVVLQYLSALMQGRLVCRGADERTQAAERLRHDAAQLQQLFLSLGLEENAHCAPVLLALRELLNLRDPALLGLEVAGLRQQFPDVSEDHVSALLGLRGDLSREQHLAALSSLQAALPPSPRASRRVLFSLVPAPALAPASCLPSGSCARALLLAE

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H3BTH9H3BTH9_HUMANEXOC3L1181
H3BRW6H3BRW6_HUMANEXOC3L180
H3BPA4H3BPA4_HUMANEXOC3L1684
F5H4W1F5H4W1_HUMANEXOC3L1679

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict187in Ref. 5; BAB84916
Sequence conflict499in Ref. 1; AAP12545 and 5; BAB84916
Sequence conflict701-707in Ref. 2; BAC03991

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY255669
EMBL· GenBank· DDBJ
AAP12545.1
EMBL· GenBank· DDBJ
mRNA
AK092858
EMBL· GenBank· DDBJ
BAC03991.1
EMBL· GenBank· DDBJ
mRNA
AK292004
EMBL· GenBank· DDBJ
BAF84693.1
EMBL· GenBank· DDBJ
mRNA
AC040160
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC074143
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471092
EMBL· GenBank· DDBJ
EAW83092.1
EMBL· GenBank· DDBJ
Genomic DNA
AK074090
EMBL· GenBank· DDBJ
BAB84916.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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