Q86VI1 · EX3L1_HUMAN
- ProteinExocyst complex component 3-like protein
- GeneEXOC3L1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids746 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | exocyst | |
Cellular Component | secretory granule | |
Cellular Component | transport vesicle | |
Molecular Function | SNARE binding | |
Biological Process | exocyst localization | |
Biological Process | exocytosis | |
Biological Process | peptide hormone secretion |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExocyst complex component 3-like protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86VI1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with insulin granules.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_037002 | 75 | in a breast cancer sample; somatic mutation; dbSNP:rs117403380 | |||
Sequence: Y → N | ||||||
Natural variant | VAR_037003 | 514 | in a breast cancer sample; somatic mutation; dbSNP:rs142958191 | |||
Sequence: A → D | ||||||
Natural variant | VAR_036959 | 561 | in dbSNP:rs9939768 | |||
Sequence: Q → E | ||||||
Natural variant | VAR_036960 | 634 | in dbSNP:rs16957212 | |||
Sequence: S → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 905 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000309474 | 1-746 | Exocyst complex component 3-like protein | |||
Sequence: MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRSREVQRTCSLESRLKSVMQSYLEGVQTGVWQLAQAIEVVQGTREALSQARGLLQGMSQALQTLEPLRERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFLEAYVSLRELEQLREDTWAPLGGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPALLVAAVRVAEVETGRTTPLGQVPRDWRQRCLRALQEGLEQAHFGSPLLPAPGALPGWLEALRVALPVELATAEALVAPCCPPQYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADAFALLHWALHVYLGQEMMGSLELGPEADVSQLEPLLTLENIEQLEATFVANIQASVSQWLQNALDGEVAEWGREHGPNTDPSGSYYSPMPAIVLQILEENIRVASLVSESLQQRVHGMALSELGTFLRSFSDALIRFSRDHFRGKSMAPHYVPYLLAALNHKSALSSSVSVLQLDGAPSGALAPVEAALDELQRRIYRLVLEALQAELQPLFADLPSRQWLSSPELLQSVCERTGRFCRDFWRVRNPTVQLLLAEAERAVVLQYLSALMQGRLVCRGADERTQAAERLRHDAAQLQQLFLSLGLEENAHCAPVLLALRELLNLRDPALLGLEVAGLRQQFPDVSEDHVSALLGLRGDLSREQHLAALSSLQAALPPSPRASRRVLFSLVPAPALAPASCLPSGSCARALLLAE |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q86VI1 | ARL14 Q8N4G2 | 3 | EBI-2813180, EBI-3921493 | |
BINARY | Q86VI1 | CEACAM6 P40199 | 3 | EBI-2813180, EBI-4314501 | |
BINARY | Q86VI1 | HGS O14964 | 3 | EBI-2813180, EBI-740220 | |
BINARY | Q86VI1 | KRT27 Q7Z3Y8 | 3 | EBI-2813180, EBI-3044087 | |
BINARY | Q86VI1 | LDB2 O43679 | 3 | EBI-2813180, EBI-2865580 | |
BINARY | Q86VI1 | MYOD1 P15172 | 3 | EBI-2813180, EBI-488878 | |
BINARY | Q86VI1 | TFIP11 Q9UBB9 | 3 | EBI-2813180, EBI-1105213 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MDSAAKDEMQPALSPGPEWPEQE | ||||||
Region | 1-370 | Mediates interaction with EXOC2, EXOC4 and EXOC5 | ||||
Sequence: MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRPEQLARLGQYRSREVQRTCSLESRLKSVMQSYLEGVQTGVWQLAQAIEVVQGTREALSQARGLLQGMSQALQTLEPLRERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFLEAYVSLRELEQLREDTWAPLGGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPALLVAAVRVAEVETGRTTPLGQVPRDWRQRCLRALQEGLEQAHFGSPLLPAPGALPGWLEALRVALPVELATAEALVAPCCPPQYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADAFALLHWALHVYLGQEMMGSLELGPEADVSQLEPLLT |
Sequence similarities
Belongs to the SEC6 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length746
- Mass (Da)81,678
- Last updated2009-02-10 v2
- ChecksumC762DE3E63D782C9
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 187 | in Ref. 5; BAB84916 | ||||
Sequence: V → F | ||||||
Sequence conflict | 499 | in Ref. 1; AAP12545 and 5; BAB84916 | ||||
Sequence: S → G | ||||||
Sequence conflict | 701-707 | in Ref. 2; BAC03991 | ||||
Sequence: Missing |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY255669 EMBL· GenBank· DDBJ | AAP12545.1 EMBL· GenBank· DDBJ | mRNA | ||
AK092858 EMBL· GenBank· DDBJ | BAC03991.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292004 EMBL· GenBank· DDBJ | BAF84693.1 EMBL· GenBank· DDBJ | mRNA | ||
AC040160 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC074143 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471092 EMBL· GenBank· DDBJ | EAW83092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK074090 EMBL· GenBank· DDBJ | BAB84916.1 EMBL· GenBank· DDBJ | mRNA |