Q86V88 · MGDP1_HUMAN

  • Protein
    Magnesium-dependent phosphatase 1
  • Gene
    MDP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Inhibited by vanadate and zinc, and slightly by calcium.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site11Nucleophile
Binding site11Mg2+ (UniProtKB | ChEBI)
Binding site12phosphate (UniProtKB | ChEBI)
Active site13Proton donor
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site13phosphate (UniProtKB | ChEBI)
Binding site20substrate
Binding site69phosphate (UniProtKB | ChEBI)
Binding site70phosphate (UniProtKB | ChEBI)
Binding site70substrate
Binding site100phosphate (UniProtKB | ChEBI)
Binding site123Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionacid phosphatase activity
Molecular Functionmetal ion binding
Molecular Functionprotein tyrosine phosphatase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      MDP1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q86V88
  • Secondary accessions
    • Q86Y84
    • Q8NAD9

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 355 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000688271-176UniProtMagnesium-dependent phosphatase 1
Modified residue (large scale data)167PRIDEPhosphoserine
Modified residue (large scale data)168PRIDEPhosphoserine
Modified residue (large scale data)172PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Gene expression databases

    • ENSG00000213920Expressed in male germ line stem cell (sensu Vertebrata) in testis and 96 other cell types or tissues

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the HAD-like hydrolase superfamily.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q86V88-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    176
  • Mass (Da)
    20,109
  • Last updated
    2003-06-01 v1
  • Checksum
    B0A33BD02458B2EF
MARLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQDVRLYPEVPEVLKRLQSLGVPGAAASRTSEIEGANQLLELFDLFRYFVHREIYPGSKITHFERLQQKTGIPFSQMIFFDDERRNIVDVSKLGVTCIHIQNGMNLQTLSQGLETFAKAQTGPLRSSLEESPFEA

Q86V88-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 107-127: LQQKTGIPFSQMIFFDDERRN → YAEIREEQGEKVSERPGKPRY
    • 128-176: Missing

Q86V88-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 89-122: YFVHREIYPGSKITHFERLQQKTGIPFSQMIFFD → CYLHSHPEWNESSNSKSRVRDICEGPNWAFEVQP
    • 123-176: Missing

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_01598589-122in isoform 3
Alternative sequenceVSP_015986107-127in isoform 2
Alternative sequenceVSP_015988123-176in isoform 3
Alternative sequenceVSP_015987128-176in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK092821
EMBL· GenBank· DDBJ
BAC03984.1
EMBL· GenBank· DDBJ
mRNA
BC046912
EMBL· GenBank· DDBJ
AAH46912.1
EMBL· GenBank· DDBJ
mRNA
BC051382
EMBL· GenBank· DDBJ
AAH51382.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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