X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 25-220 IN COMPLEX WITH ACETYL-COA AND SUBSTRATE, FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF TYR-85; TRP-90; GLU-100; 127-ASP--GLU-129; TYR-136; CYS-137; TYR-138; GLU-139; THR-174 AND TYR-211
The findings strengthen the importance of NAA40 to maintain colorectal cancer cell growth. We show that NAA40 oncogenic properties stimulate the global levels of H4R3me2s by transcriptionally activating PRMT5 methyltransferase which in turn modulates the expression of key downstream cancer-related genes.
NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue leading to the upregulation of Slug and lung cancer progression.
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