Q86UQ0 · ZN589_HUMAN

  • Protein
    Zinc finger protein 589
  • Gene
    ZNF589
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

The subsequence ALPAKDSAWPWEEKPRYLGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQ, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 589
  • Alternative names
    • Stem cell zinc finger protein 1

Gene names

    • Name
      ZNF589
    • Synonyms
      SZF1
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q86UQ0
  • Secondary accessions
    • Q86UC9
    • Q9BRI6
    • Q9BRY3
    • Q9Y611
    • Q9Y612

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05287112in dbSNP:rs9847953
Natural variantVAR_035290216in dbSNP:rs11718329

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 441 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003063251-364UniProtZinc finger protein 589
Modified residue190UniProtPhosphoserine
Modified residue (large scale data)190PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34+ cells.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with TRIM28.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Domain35-108KRAB
Region103-148Disordered
Compositional bias130-148Basic and acidic residues
Zinc finger248-270C2H2-type 1
Zinc finger276-298C2H2-type 2
Zinc finger304-326C2H2-type 3
Zinc finger332-354C2H2-type 4

Domain

The KRAB domain mediates interaction with TRIM28.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q86UQ0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    364
  • Mass (Da)
    41,189
  • Last updated
    2003-06-01 v1
  • Checksum
    EC335916B88993E3
MWAPREQLLGWTAEALPAKDSAWPWEEKPRYLGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVTFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREKSELIKHQRIHTGDKPYVCRD

Q86UQ0-2

  • Name
    2
  • Synonyms
    SZF1-2
  • Note
    Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-32: MWAPREQLLGWTAEALPAKDSAWPWEEKPRYL → MIDFQMLNQLCRTIINPSVIPCLKYCGDQI
    • 75-75: Missing

Q86UQ0-3

  • Name
    3
  • Synonyms
    SZF1-1
  • Note
    Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-32: MWAPREQLLGWTAEALPAKDSAWPWEEKPRYL → MIDFQMLNQLCRTIINPSVIPCLKYCGDQI
    • 75-75: Missing
    • 353-364: IHTGDKPYVCRD → CQVTVPLEEWSLHLTTSFCNCVLPLASMTLSCFIFFYISSLCCFLSYPTFRFYSEFSLQPYNLRDTFTRSPS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
C9J1J1C9J1J1_HUMANZNF58996
B4DQF9B4DQF9_HUMANZNF589177
F8VZ09F8VZ09_HUMANZNF58989
C9JGA6C9JGA6_HUMANZNF58980

Sequence caution

The sequence AAH05859.2 differs from that shown. Reason: Erroneous initiation
The sequence AAH06247.2 differs from that shown. Reason: Erroneous initiation
The sequence AAH48798.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0284491-32in isoform 2 and isoform 3
Alternative sequenceVSP_02845075in isoform 2 and isoform 3
Compositional bias130-148Basic and acidic residues
Alternative sequenceVSP_028451353-364in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF114816
EMBL· GenBank· DDBJ
AAD38879.1
EMBL· GenBank· DDBJ
mRNA
AF114817
EMBL· GenBank· DDBJ
AAD38880.1
EMBL· GenBank· DDBJ
mRNA
AY258146
EMBL· GenBank· DDBJ
AAP14679.1
EMBL· GenBank· DDBJ
mRNA
AL832831
EMBL· GenBank· DDBJ
CAI46129.1
EMBL· GenBank· DDBJ
mRNA
CH471055
EMBL· GenBank· DDBJ
EAW64856.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005859
EMBL· GenBank· DDBJ
AAH05859.2
EMBL· GenBank· DDBJ
mRNA Different initiation
BC006247
EMBL· GenBank· DDBJ
AAH06247.2
EMBL· GenBank· DDBJ
mRNA Different initiation
BC048798
EMBL· GenBank· DDBJ
AAH48798.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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