Q86UE9 · Q86UE9_HUMAN
- ProteinSolute carrier family 15 member 2
- GeneSLC15A2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids729 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- 2 H+(out) + L-alanyl-L-alanine(out) = 2 H+(in) + L-alanyl-L-alanine(in)This reaction proceeds in the forward direction.
2 H+ (out)CHEBI:15378+ L-alanyl-L-alanine (out)CHEBI:195181= 2 H+ (in)CHEBI:15378+ L-alanyl-L-alanine (in)CHEBI:195181 - 3 H+(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 3 H+(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)This reaction proceeds in the forward direction.
- a dipeptide(out) + 2 H+(out) = a dipeptide(in) + 2 H+(in)This reaction proceeds in the forward direction.
- an L-amino acid tripeptide(out) + 2 H+(out) = an L-amino acid tripeptide(in) + 2 H+(in)This reaction proceeds in the forward direction.
- carnosine(out) + 2 H+(out) = carnosine(in) + 2 H+(in)This reaction proceeds in the forward direction.
- glycyl-L-glutamate(out) + 3 H+(out) = glycyl-L-glutamate(in) + 3 H+(in)This reaction proceeds in the forward direction.
- glycyl-L-leucine(out) + 2 H+(out) = glycyl-L-leucine + 2 H+(in)This reaction proceeds in the forward direction.
- glycyl-L-lysine(out) + 2 H+(out) = glycyl-L-lysine(in) + 2 H+(in)This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | phagocytic vesicle membrane | |
Molecular Function | dipeptide transmembrane transporter activity | |
Molecular Function | symporter activity | |
Biological Process | dipeptide import across plasma membrane | |
Biological Process | innate immune response | |
Biological Process | peptide transport | |
Biological Process | protein transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 15 member 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86UE9
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 58-78 | Helical | ||||
Sequence: FSYYGMKAVLILYFLYFLHWN | ||||||
Transmembrane | 84-104 | Helical | ||||
Sequence: SIYHAFSSLCYFTPILGAAIA | ||||||
Transmembrane | 116-137 | Helical | ||||
Sequence: YLSLVYVLGHVIKSLGALPILG | ||||||
Transmembrane | 143-164 | Helical | ||||
Sequence: TVLSLIGLSLIALGTGGIKPCV | ||||||
Transmembrane | 185-205 | Helical | ||||
Sequence: SVFYLSINAGSLISTFITPML | ||||||
Transmembrane | 217-237 | Helical | ||||
Sequence: YALAFGVPGLLMVIALVVFAM | ||||||
Transmembrane | 298-316 | Helical | ||||
Sequence: ALTRVLFLYIPLPMFWALL | ||||||
Transmembrane | 346-367 | Helical | ||||
Sequence: VLNPLLVLIFIPLFDFVIYRLV | ||||||
Transmembrane | 379-397 | Helical | ||||
Sequence: KMAVGMILACLAFAVAAAV | ||||||
Transmembrane | 647-669 | Helical | ||||
Sequence: AAWLLTIAVGNIIVLVVAQFSGL | ||||||
Transmembrane | 675-697 | Helical | ||||
Sequence: FILFSCLLLVICLIFSIMGYYYV |
Keywords
- Cellular component
PTM/Processing
Interaction
Subunit
Interacts (via extracellular domain region) with trypsin.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-34 | Disordered | ||||
Sequence: MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPS | ||||||
Compositional bias | 20-34 | Pro residues | ||||
Sequence: EEVPPRPPSPPKKPS |
Sequence similarities
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length729
- Mass (Da)81,753
- Last updated2003-06-01 v1
- Checksum017C88004A874E97
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 20-34 | Pro residues | ||||
Sequence: EEVPPRPPSPPKKPS |