Q86UE6 · LRRT1_HUMAN
- ProteinLeucine-rich repeat transmembrane neuronal protein 1
- GeneLRRTM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids522 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.
Miscellaneous
This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | excitatory synapse | |
Cellular Component | extracellular matrix | |
Cellular Component | extracellular space | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | glutamatergic synapse | |
Cellular Component | growth cone | |
Cellular Component | postsynaptic specialization membrane | |
Biological Process | establishment of localization in cell | |
Biological Process | exploration behavior | |
Biological Process | locomotory behavior | |
Biological Process | long-term synaptic potentiation | |
Biological Process | negative regulation of receptor internalization | |
Biological Process | positive regulation of synapse assembly | |
Biological Process | protein localization to synapse | |
Biological Process | receptor internalization | |
Biological Process | regulation of postsynaptic density assembly | |
Biological Process | regulation of presynapse assembly | |
Biological Process | synapse organization |
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLeucine-rich repeat transmembrane neuronal protein 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86UE6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Postsynaptic cell membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 35-427 | Extracellular | ||||
Sequence: APSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAENAVQIHK | ||||||
Transmembrane | 428-448 | Helical | ||||
Sequence: VVTGTMALIFSFLIVVLVLYV | ||||||
Topological domain | 449-522 | Cytoplasmic | ||||
Sequence: SWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_022681 | 330 | in dbSNP:rs6733871 | |||
Sequence: N → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 804 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-34 | |||||
Sequence: MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPA | ||||||
Chain | PRO_0000018350 | 35-522 | Leucine-rich repeat transmembrane neuronal protein 1 | |||
Sequence: APSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV | ||||||
Glycosylation | 56 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 63 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 130 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 380 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Predominantly expressed in forebrain regions including thalamus and cerebral cortex.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 35-63 | LRRNT | ||||
Sequence: APSGCPQLCRCEGRLLYCEALNLTEAPHN | ||||||
Repeat | 64-87 | LRR 1 | ||||
Sequence: LSGLLGLSLRYNSLSELRAGQFTG | ||||||
Repeat | 89-111 | LRR 2 | ||||
Sequence: MQLTWLYLDHNHICSVQGDAFQK | ||||||
Repeat | 112-135 | LRR 3 | ||||
Sequence: LRRVKELTLSSNQITQLPNTTFRP | ||||||
Repeat | 137-159 | LRR 4 | ||||
Sequence: PNLRSVDLSYNKLQALAPDLFHG | ||||||
Repeat | 161-183 | LRR 5 | ||||
Sequence: RKLTTLHMRANAIQFVPVRIFQD | ||||||
Repeat | 184-207 | LRR 6 | ||||
Sequence: CRSLKFLDIGYNQLKSLARNSFAG | ||||||
Repeat | 209-231 | LRR 7 | ||||
Sequence: FKLTELHLEHNDLVKVNFAHFPR | ||||||
Repeat | 233-255 | LRR 8 | ||||
Sequence: ISLHSLCLRRNKVAIVVSSLDWV | ||||||
Repeat | 256-278 | LRR 9 | ||||
Sequence: WNLEKMDLSGNEIEYMEPHVFET | ||||||
Repeat | 279-302 | LRR 10 | ||||
Sequence: VPHLQSLQLDSNRLTYIEPRILNS | ||||||
Domain | 314-365 | LRRCT | ||||
Sequence: NLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED | ||||||
Region | 382-401 | Disordered | ||||
Sequence: SDLGPPASSATTLADGGEGQ |
Sequence similarities
Belongs to the LRRTM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length522
- Mass (Da)58,641
- Last updated2007-03-06 v2
- Checksum730004673B14245C
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 503 | in Ref. 1; AAO67545 and 2; BAB71240 | ||||
Sequence: I → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY182024 EMBL· GenBank· DDBJ | AAO67545.1 EMBL· GenBank· DDBJ | mRNA | ||
AK056644 EMBL· GenBank· DDBJ | BAB71240.1 EMBL· GenBank· DDBJ | mRNA | ||
AK290512 EMBL· GenBank· DDBJ | BAF83201.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358310 EMBL· GenBank· DDBJ | AAQ88677.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471053 EMBL· GenBank· DDBJ | EAW99566.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471053 EMBL· GenBank· DDBJ | EAW99567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC045113 EMBL· GenBank· DDBJ | AAH45113.1 EMBL· GenBank· DDBJ | mRNA |