Q86UE3 · ZN546_HUMAN
- ProteinZinc finger protein 546
- GeneZNF546
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids836 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Community annotation
The subsequence EETQGELTSSCGSKTMANVSLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPW, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Source | Submission date | Contributor |
---|---|---|
PubMed:33326746 | 0000-0002-4108-0575 |
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 546
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ86UE3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_035587 | 15 | in a breast cancer sample; somatic mutation | |||
Sequence: L → V | ||||||
Natural variant | VAR_055271 | 201 | in dbSNP:rs17854378 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_055272 | 243 | in dbSNP:rs2111543 | |||
Sequence: R → T | ||||||
Natural variant | VAR_055273 | 253 | in dbSNP:rs2111544 | |||
Sequence: A → V | ||||||
Natural variant | VAR_055274 | 298 | in dbSNP:rs17710336 | |||
Sequence: V → E | ||||||
Natural variant | VAR_055275 | 427 | in dbSNP:rs12460371 | |||
Sequence: E → G | ||||||
Natural variant | VAR_055276 | 452 | in dbSNP:rs7255186 | |||
Sequence: L → F | ||||||
Natural variant | VAR_055277 | 652 | in dbSNP:rs12373540 | |||
Sequence: L → F |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 965 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000234582 | 1-836 | Zinc finger protein 546 | |||
Sequence: MQVDPPLHGPPNDFLIFQIIPLHSLSIMPRFLWILCFSMEETQGELTSSCGSKTMANVSLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWIVMREGTRNWFTDLEYKYITKNLLSEKNVCKIYLSQLQTGEKSKNTIHEDTIFRNGLQCKHEFERQERHQMGCVSQMLIQKQISHPLHPKIHAREKSYECKECRKAFRQQSYLIQHLRIHTGERPYKCMECGKAFCRVGDLRVHHTIHAGERPYECKECGKAFRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRDLRVHQTIHAGERPYECKECGKAFRLHYQLTEHQRIHTGERPYECKVCGKTFRVQRHISQHQKIHTGVKPYKCNECGKAFSHGSYLVQHQKIHTGEKPYECKECGKSFSFHAELARHRRIHTGEKPYECRECGKAFRLQTELTRHHRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSNQFISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQTELTQHHRIHTGEKPYKCTECGKAFIRSTHLTQHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYICNECGNAFICSYRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHFRLHTGEKPYSCKECGNAFRLQAELTRHHIVHTGEKPYKCKECGKAFSVNSELTRHHRIHTGEKPYQCKECGKAFIRSDQLTLHQRNHISEEVLCIM | ||||||
Cross-link | 179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 60-131 | KRAB | ||||
Sequence: LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWIVMREGTRNWFT | ||||||
Zinc finger | 217-239 | C2H2-type 1 | ||||
Sequence: YECKECRKAFRQQSYLIQHLRIH | ||||||
Zinc finger | 245-267 | C2H2-type 2 | ||||
Sequence: YKCMECGKAFCRVGDLRVHHTIH | ||||||
Zinc finger | 273-295 | C2H2-type 3 | ||||
Sequence: YECKECGKAFRLHYHLTEHQRIH | ||||||
Zinc finger | 301-323 | C2H2-type 4 | ||||
Sequence: YECKECGKAFSRVRDLRVHQTIH | ||||||
Zinc finger | 329-351 | C2H2-type 5 | ||||
Sequence: YECKECGKAFRLHYQLTEHQRIH | ||||||
Zinc finger | 357-379 | C2H2-type 6 | ||||
Sequence: YECKVCGKTFRVQRHISQHQKIH | ||||||
Zinc finger | 385-407 | C2H2-type 7 | ||||
Sequence: YKCNECGKAFSHGSYLVQHQKIH | ||||||
Zinc finger | 413-435 | C2H2-type 8 | ||||
Sequence: YECKECGKSFSFHAELARHRRIH | ||||||
Zinc finger | 441-463 | C2H2-type 9 | ||||
Sequence: YECRECGKAFRLQTELTRHHRTH | ||||||
Zinc finger | 469-491 | C2H2-type 10 | ||||
Sequence: YECKECGKAFICGYQLTLHLRTH | ||||||
Zinc finger | 497-519 | C2H2-type 11 | ||||
Sequence: YECKECGKTFSSRYHLTQHYRIH | ||||||
Zinc finger | 525-547 | C2H2-type 12 | ||||
Sequence: YICNECGKAFRLQGELTRHHRIH | ||||||
Zinc finger | 553-575 | C2H2-type 13 | ||||
Sequence: YECKECGKAFIHSNQFISHQRIH | ||||||
Zinc finger | 581-603 | C2H2-type 14 | ||||
Sequence: YICKECGKIFSRRYNLTQHFKIH | ||||||
Zinc finger | 609-631 | C2H2-type 15 | ||||
Sequence: YICNECGKAFRFQTELTQHHRIH | ||||||
Zinc finger | 637-659 | C2H2-type 16 | ||||
Sequence: YKCTECGKAFIRSTHLTQHHRIH | ||||||
Zinc finger | 665-687 | C2H2-type 17 | ||||
Sequence: YECTECGKTFSRHYHLTQHHRGH | ||||||
Zinc finger | 693-715 | C2H2-type 18 | ||||
Sequence: YICNECGNAFICSYRLTLHQRIH | ||||||
Zinc finger | 721-743 | C2H2-type 19 | ||||
Sequence: YECKECGKTFSRRYHLTQHFRLH | ||||||
Zinc finger | 749-771 | C2H2-type 20 | ||||
Sequence: YSCKECGNAFRLQAELTRHHIVH | ||||||
Zinc finger | 777-799 | C2H2-type 21 | ||||
Sequence: YKCKECGKAFSVNSELTRHHRIH | ||||||
Zinc finger | 805-827 | C2H2-type 22 | ||||
Sequence: YQCKECGKAFIRSDQLTLHQRNH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length836
- Mass (Da)98,405
- Last updated2009-05-05 v2
- Checksum81AC4B259DDBCB32
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK292528 EMBL· GenBank· DDBJ | BAF85217.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471126 EMBL· GenBank· DDBJ | EAW56930.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC045649 EMBL· GenBank· DDBJ | AAH45649.1 EMBL· GenBank· DDBJ | mRNA |