Q86UE3 · ZN546_HUMAN

  • Protein
    Zinc finger protein 546
  • Gene
    ZNF546
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May be involved in transcriptional regulation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

Community annotation

The subsequence EETQGELTSSCGSKTMANVSLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPW, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.

SourceSubmission dateContributor
PubMed:333267460000-0002-4108-0575

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 546
  • Alternative names
    • Zinc finger protein 49

Gene names

    • Name
      ZNF546
    • Synonyms
      ZNF49

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q86UE3
  • Secondary accessions
    • A8K913

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03558715in a breast cancer sample; somatic mutation
Natural variantVAR_055271201in dbSNP:rs17854378
Natural variantVAR_055272243in dbSNP:rs2111543
Natural variantVAR_055273253in dbSNP:rs2111544
Natural variantVAR_055274298in dbSNP:rs17710336
Natural variantVAR_055275427in dbSNP:rs12460371
Natural variantVAR_055276452in dbSNP:rs7255186
Natural variantVAR_055277652in dbSNP:rs12373540

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 965 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00002345821-836Zinc finger protein 546
Cross-link179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, zinc finger.

TypeIDPosition(s)Description
Domain60-131KRAB
Zinc finger217-239C2H2-type 1
Zinc finger245-267C2H2-type 2
Zinc finger273-295C2H2-type 3
Zinc finger301-323C2H2-type 4
Zinc finger329-351C2H2-type 5
Zinc finger357-379C2H2-type 6
Zinc finger385-407C2H2-type 7
Zinc finger413-435C2H2-type 8
Zinc finger441-463C2H2-type 9
Zinc finger469-491C2H2-type 10
Zinc finger497-519C2H2-type 11
Zinc finger525-547C2H2-type 12
Zinc finger553-575C2H2-type 13
Zinc finger581-603C2H2-type 14
Zinc finger609-631C2H2-type 15
Zinc finger637-659C2H2-type 16
Zinc finger665-687C2H2-type 17
Zinc finger693-715C2H2-type 18
Zinc finger721-743C2H2-type 19
Zinc finger749-771C2H2-type 20
Zinc finger777-799C2H2-type 21
Zinc finger805-827C2H2-type 22

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    836
  • Mass (Da)
    98,405
  • Last updated
    2009-05-05 v2
  • Checksum
    81AC4B259DDBCB32
MQVDPPLHGPPNDFLIFQIIPLHSLSIMPRFLWILCFSMEETQGELTSSCGSKTMANVSLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWIVMREGTRNWFTDLEYKYITKNLLSEKNVCKIYLSQLQTGEKSKNTIHEDTIFRNGLQCKHEFERQERHQMGCVSQMLIQKQISHPLHPKIHAREKSYECKECRKAFRQQSYLIQHLRIHTGERPYKCMECGKAFCRVGDLRVHHTIHAGERPYECKECGKAFRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRDLRVHQTIHAGERPYECKECGKAFRLHYQLTEHQRIHTGERPYECKVCGKTFRVQRHISQHQKIHTGVKPYKCNECGKAFSHGSYLVQHQKIHTGEKPYECKECGKSFSFHAELARHRRIHTGEKPYECRECGKAFRLQTELTRHHRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSNQFISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQTELTQHHRIHTGEKPYKCTECGKAFIRSTHLTQHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYICNECGNAFICSYRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHFRLHTGEKPYSCKECGNAFRLQAELTRHHIVHTGEKPYKCKECGKAFSVNSELTRHHRIHTGEKPYQCKECGKAFIRSDQLTLHQRNHISEEVLCIM

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0R292M0R292_HUMANZNF546124
M0QY24M0QY24_HUMANZNF546810
M0QXR6M0QXR6_HUMANZNF546139
M0QXH5M0QXH5_HUMANZNF546126
M0QZB2M0QZB2_HUMANZNF54637
A0A494C1I4A0A494C1I4_HUMANZNF54673

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK292528
EMBL· GenBank· DDBJ
BAF85217.1
EMBL· GenBank· DDBJ
mRNA
CH471126
EMBL· GenBank· DDBJ
EAW56930.1
EMBL· GenBank· DDBJ
Genomic DNA
BC045649
EMBL· GenBank· DDBJ
AAH45649.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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